Evidence map›Paper›PMID 40635785›Full record

ArticleJournal of aerosol science2025

Dynamic of infectious aerosols generated by cough from patients with pulmonary tuberculosis.

Taline Canto Tristão, Mariana Abou Mourad Ferreira, Pedro Sousa de Almeida Júnior, Luiz Guilherme Schmidt Castellani, Manuela Negrelli Brunetti, Edward C Jones-López, Kevin P Fennelly, Michael R Barer, Carlos Henrique Fantecelle, Saulo Almeida Morellato and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of aerosol science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Taline Canto TristãoNúcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, 1468 Marechal Campos Avenue 29047-105, Vitória, Espírito Santo, Brazil.
Mariana Abou Mourad FerreiraNúcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, 1468 Marechal Campos Avenue 29047-105, Vitória, Espírito Santo, Brazil.
Pedro Sousa de Almeida JúniorNúcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, 1468 Marechal Campos Avenue 29047-105, Vitória, Espírito Santo, Brazil.
Luiz Guilherme Schmidt CastellaniNúcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, 1468 Marechal Campos Avenue 29047-105, Vitória, Espírito Santo, Brazil.
Manuela Negrelli BrunettiNúcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, 1468 Marechal Campos Avenue 29047-105, Vitória, Espírito Santo, Brazil.
Edward C Jones-LópezDivision of Infectious Diseases, Department of Medicine, Keck School of Medicine of USC, 1975 Zonal Ave. University of Southern California, Los Angeles, CA 90033, USA.
Kevin P FennellySection of Infectious Diseases, Department of Medicine, Boston University School of Medicine and Boston Medical Center, 725 Albany Street, Boston 02118, MA, USA.
Michael R BarerDepartment of Respiratory Sciences, University of Leicester, University Road, LE1 7RH, Leicester, UK.
Carlos Henrique FantecelleNúcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, 1468 Marechal Campos Avenue 29047-105, Vitória, Espírito Santo, Brazil.
Saulo Almeida MorellatoDepartamento de Estatística, Centro de Ciências Exatas, Universidade Federal do Espírito Santo, 514 Fernando Ferrari Avenue, Vitória, 29075-053, Espírito Santo, Brazil.
David Jamil HadadNúcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, 1468 Marechal Campos Avenue 29047-105, Vitória, Espírito Santo, Brazil.
Jerrold J EllnerPulmonary Branch; Division of Intramural Research; National Heart, Lung, and Blood Institute, National Institutes of Health, 31 Center Dr, Bethesda, MD 20892, USA.
Reynaldo DietzeNúcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, 1468 Marechal Campos Avenue 29047-105, Vitória, Espírito Santo, Brazil.
Moisés PalaciNúcleo de Doenças Infecciosas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, 1468 Marechal Campos Avenue 29047-105, Vitória, Espírito Santo, Brazil.

Funding

Validation and Application of a Model for Human-like TB Latency in RabbitsU19AI111276 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI ALLAND, DAVID, HORSBURGH, CHARLES ROBERT · 2014 to 2020
$23.3M
US-Brazil Research Collaboration on Strain Variation in TBU01AI065663 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI ELLNER, JERROLD J. · 2005 to 2015
$5.2M
NIAID NIH HHS U01 AI065663NIAID NIH HHS U19 AI111276
6 · The paper itself

Abstract

Tuberculosis (TB) is an ancient disease transmitted through aerosols frequently generated by coughing and it is still unknown whether there is variability in cough aerosol output throughout the day and whether this may impact patients' infectivity categorization. To study the dynamic of infectious aerosols generated by cough, we conducted a cross-sectional study on pulmonary TB patients (n=16) who had their cough-generated aerosols sampled twice daily for two consecutive days for the Cough Aerosol Sampling System (CASS) assay. Most patients were classified as Variable Low Producers and Variable High Producers (n=10; 62.5%), followed by Negative Producers (n = 4; 25%) and Consistent Producers (n = 2; 12.5%). Additionally, most recovered bacilli (88.7 %) within a respiratory aerosol size range. Although the time of collection did not appear to impact on aerosol infectivity, performing CASS with multiple samples allowed for more accurate detection and distinction among aerosol producers.

Indexed as

aerosolscoughMycobacterium tuberculosistuberculosis

Identifiers

PMID40635785
PMCPMC12237428

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.