ArticleFood science & nutrition2025
MTA-TST Axis-Mediated Apoptosis Activation: A Multi-Omics Insight Into High-Protein Diet's Anti-Adiposity Effect.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- MTA-TST Axis-Mediated Apoptosis Activation: A Multi-Omics Insight Into High-Protein Diet's Anti-Adiposity Effect.Food science & nutrition · 2025Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
To explore the mechanism of a high-protein diet (named high protein and rich fat diet, HPRFD) with weight loss effect regulating visceral fat metabolism through endogenous metabolites. Non-targeted metabonomics compared the spectrum of different metabolites in different groups of experimental mice, and targeted metabonomics examined the target metabolite in visceral adipose tissue (VAT). VAT transcriptomics identified differentially expressed genes. Multi-mics joint analysis identified target metabolites, genes, and their relationships. Functional annotation revealed shared signaling pathways. 3T3-L1 adipocytes were treated with metabolites to observe changes in morphology, mitochondrial function, and expression of key genes in the signal pathway. The gene knockdown experiment evaluated the changes in key metabolites in the above functions of cells. Molecular docking predicted metabolite-protein binding sites. The results showed that 5'-deoxy-5'-(methylthio)adenosine (MTA) was significantly elevated in the HPRFD group (
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