Evidence map›Paper›PMID 40635718›Full record

ArticleInternational journal of nanomedicine2025

Boosting Hydroxyl Radical Generation with Nitrogen Vacancy-Modified Carbon Nitride for Triggering Dual Damage of Cancer Nucleus DNA-Mitochondria against Hypoxic Tumors.

Yuan Zhang, Meixian Liu, Shuyun Xue, Na Li, Jinjia Hong, Jiawen Gu, Xiaoyan Ren, Huifei Li, Jie Xu, Chengxi Zhang and 3 more

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuan Zhang *Department of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People's Republic of China.
Meixian Liu *Department of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People's Republic of China.
Shuyun XueDepartment of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People's Republic of China.
Na LiDepartment of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People's Republic of China.
Jinjia HongDepartment of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People's Republic of China.
Jiawen GuDepartment of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People's Republic of China.
Xiaoyan RenDepartment of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People's Republic of China.
Huifei LiDepartment of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People's Republic of China.
Jie XuDepartment of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People's Republic of China.
Chengxi ZhangDepartment of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People's Republic of China.
Tianqi LiangDepartment of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People's Republic of China.
Bin ZhaoDepartment of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People's Republic of China.
Xing WangDepartment of Oral and Maxillofacial Surgery, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Oral squamous cell carcinoma (OSCC) is a prevalent and deadly cancer, with over 350,000 new cases yearly. A hypoxic tumor microenvironment is the bottleneck of photodynamic therapy (PDT) and significantly weakens overall therapeutic efficacy. Methods: In this study, we introduce nitrogen vacancy-modified PCN (N Results: The introduction of N Conclusion: Collectively, the high •OH-generation efficiency, strong anticancer activity, and overall safety of the O

Indexed as

Carcinoma, Squamous CellHydroxyl RadicalMouth NeoplasmsNitrilesPhotosensitizing AgentsAnimalsCell Line, TumorCell NucleusChlorophyllidesDNA DamageHumansHydrogen PeroxideMiceMice, Inbred BALB CMice, NudeMitochondriaChlorophyllidescyanogenHydrogen PeroxideHydroxyl RadicalNitrilesNitrogenPhotosensitizing AgentsPorphyrinsDNA-damage repairhydroxyl radicalnitrogen vacancyphotodynamic therapypolymeric carbon nitride

Identifiers

PMID40635718
PMCPMC12239897

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.