ArticleMolecular therapy. Nucleic acids2025
Hepatocyte delivery of miR-34b/c reduces hepatic stellate cell activation and improves liver fibrosis.
Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Liver fibrosis is a major health problem worldwide and currently available treatments are only supportive. The microRNA-34 (miR-34) family is upregulated in response to chronic liver injuries, and miR-34b/c downregulates the platelet-derived growth factor signaling receptors. Mice deleted of miR-34b/c were found to be more susceptible to liver fibrosis. Adeno-associated viral (AAV) vector-mediated hepatocyte-specific expression of miR-34b/c ameliorated liver fibrosis/cirrhosis in mice. Interestingly, expression of miR-34b/c into hepatocytes inhibited hepatic stellate cell activation
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