ReviewCancer reports (Hoboken, N.J.)2025
Therapeutic Indications of Pembrolizumab in Eight Common Cancers: Current Evidence and Future Directions.
Review in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Therapeutic Indications of Pembrolizumab in Eight Common Cancers: Current Evidence and Future Directions.Cancer reports (Hoboken, N.J.) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPembrolizumab is a monoclonal antibody that inhibits the programmed death-1 (PD-1) receptor pathway, which has increasingly been implicated in cancer treatment regimens. Since its first approval for melanoma in 2014, many trials have investigated the efficacy and safety of this new drug in different cancers. In this review, we discuss the therapeutic advances achieved with pembrolizumab in the management of eight cancers that are associated with a relatively poor prognosis. We also report the FDA approvals of this drug, highlighting promising ongoing trials and potential aspects for future research. RECENT
findingsNumerous trials have demonstrated robust anti-cancer effects, high response rates, and a favorable safety profile of pembrolizumab monotherapy or its combination in different lines and treatment settings. With the encouraging survival benefits of this treatment in advanced/metastatic disease, there has been an increasing tendency to explore its therapeutic potential in early-stage disease. Thus, pembrolizumab was effectively added to the standard neoadjuvant chemotherapy regimen for resectable TNBC and NSCLC, followed by adjuvant pembrolizumab monotherapy after resection. Similar positive results were found with the adjuvant administration of pembrolizumab after surgery in resectable RCC and melanoma. Pembrolizumab has also been recently studied in locally advanced resectable gastric and gastroesophageal junction adenocarcinoma as well as early-stage estrogen receptor-positive/human epidermal growth factor receptor 2-negative breast cancer as a neoadjuvant-adjuvant regimen.
conclusionsThe advent of immunotherapeutic agents such as pembrolizumab has unprecedently altered cancer therapy regimens; however, future research efforts should address the need for biomarkers that could better identify patients who would most likely respond to such therapy and investigate new combinations that could overcome resistance to immunotherapy.
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