Evidence map›Paper›PMID 40635537›Full record

ArticleJournal of clinical neurology (Seoul, Korea)2025

Efficacy and Safety of Pregabalin for Restless Legs Syndrome in Korean Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

Jun-Sang Sunwoo, Yong Won Cho, Won Chul Shin, Jung-Ick Byun, Jung-Won Shin, Ki-Young Jung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical neurology (Seoul, Korea), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jun-Sang SunwooDepartment of Neurology, Kangbuk Samsung Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-8834-0568
Yong Won ChoDepartment of Neurology, Keimyung University School of Medicine, Daegu, Korea.ORCID https://orcid.org/0000-0002-6127-1045
Won Chul ShinDepartment of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-3044-9397
Jung-Ick ByunDepartment of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-6224-4575
Jung-Won ShinDepartment of Neurology, CHA University, CHA Bundang Medical Center, Seongnam, Korea.ORCID https://orcid.org/0000-0003-2155-9068
Ki-Young JungDepartment of Neurology, Seoul National University Hospital, Seoul National University, Medical Research Center Neuroscience Research Institute, College of Medicine, Seoul, Korea. jungky@snu.ac.kr.ORCID https://orcid.org/0000-0001-5528-9081

Funding

Pharmascience Korea
6 · The paper itself

Abstract

background and purposeTo evaluate the clinical efficacy and safety of pregabalin in Korean adults with restless legs syndrome (RLS).

methodsIn this randomized, multicenter, double-blind, placebo-controlled trial, 78 patients with RLS with an International Restless Legs Scale (IRLS) score ≥15 were randomized 1:1 to receive either pregabalin (

resultsAt baseline, the mean IRLS scores were 23.2±5.8 in the pregabalin and 24.5±5.2 in the placebo group (

conclusionsThis study failed to demonstrate the therapeutic effect of pregabalin compared with placebo for RLS in Korean adults. Possible reasons for the negative results include low dose, insufficient sample size, and substantial placebo response. Further investigations are warranted to optimize pregabalin therapy in Korean adults with RLS.

Indexed as

clinical trialpregabalinrestless legs syndrome

Identifiers

PMID40635537
PMCPMC12303681

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.