Trial reportJournal of cosmetic dermatology2025
A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Evaluating the Efficacy and Satisfaction of a Topical Product Containing Blueberry Extract and Pro-Xylane Combined With Micro-Focused Ultrasound for Anti-aging.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05748470 (A Prospective, Single-center, Single-blind, Randomized Split-face Controlled Clinical Study to Evaluate the Efficacy and Satisfaction of Ultrasound Therapy Combined With SkinCeuticals A.G.E for Improving Facial Aging in Real World Clinical Practice), which is not on this map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Single-center, Single-blind, Randomized Split-face Controlled Clinical Study to Evaluate the Efficacy and Satisfaction of Ultrasound Therapy Combined With SkinCeuticals A.G.E for Improving Facial Aging in Real World Clinical Practice
Who cites it
4 citing papers in PubMed.
- A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Evaluating the Efficacy and Satisfaction of a Topical Product Containing Blueberry Extract and Pro-Xylane Combined With Micro-Focused Ultrasound for Anti-aging.Journal of cosmetic dermatology · 2025Trial
- Age-Associated Differences in Facial Skin Structure in Chinese Women: a Cross-Sectional Study.Dermatology and therapy · 2026Article
- International Expert Consensus on Integrated Skincare Active Ingredients for Pretreatment and Posttreatment Use With Medical Aesthetic Procedures to Enhance Skin Benefits.Journal of cosmetic dermatology · 2026Article
- Clinical Efficacy of a Flavo-Proxylane Topical Regimen Pre- and Post-ultrasound Procedure for Subjects Undergoing Glucagon-Like Peptide 1 (GLP-1) Receptor Agonist Therapy.Dermatology and therapy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundMicro-focused ultrasound (MFUS) has been effective in treating skin aging, which manifests as skin thinning, reduced elasticity, wrinkling, etc.
aimsThis study aims to evaluate the efficacy and satisfaction of combining a product containing blueberry extract and Pro-xylane (A.G.E. cream) with MFUS in antiaging effects in the Chinese population.
methodsIn this randomized, investigator-blinded, controlled trial, patients aged 18-65 with skin roughness, sagging, laxity, or fine lines/wrinkles were enrolled. After MFUS, one side of patients' faces was randomly assigned to apply the A.G.E. cream and the other side with the standard moisturizer. Patients were followed up for 180 days. The primary endpoint was the Global Aesthetic Improvement Scale (GAIS). Secondary endpoints included percentage changes from baseline in fine lines, skin elasticity, dermal thickness, and transepidermal water loss. Patient and dermatologist satisfaction was evaluated using a questionnaire.
resultsA total of 50 patients were included in the study, with 49 (98%) being female. The mean ± SD age was 33.7 ± 6.4 years. For the primary endpoint, the intervention side demonstrated significant improvement in GAIS compared to the control side on Day 90 (p < 0.001). For secondary endpoints, the A.G.E. cream use after MFUS significantly improved skin elasticity at the cheeks and mouth corners on multiple follow-up days and improved fine lines at the mouth corners on Day 180. Patients and dermatologists reported higher satisfaction levels with the aesthetic outcomes of the intervention side.
conclusionsThe application of the A.G.E. cream following MFUS treatment improved skin elasticity, dermal thickness, fine lines, and patient/dermatologist satisfaction.
trial registrationClinicalTrials.gov identifier: NCT05748470.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.