ArticleInternational neurourology journal2025
Association Between Lipid Accumulation Product and Stress Urinary Incontinence in Women in the United States: The Mediating Role of Oxidative Stress.
Article in International neurourology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe relationship between lipid accumulation product (LAP) and stress urinary incontinence (SUI) in women remains unclear, and the potential mediating roles of oxidative stress and inflammatory factors in this process have not been extensively studied. This analysis aimed to explore the association between elevated LAP indices and SUI in women, specifically examining the mediating effects of oxidative stress and inflammatory factors.
methodsData from 4,292 participants across 6 consecutive cycles of the National Health and Nutrition Examination Survey were analyzed. Logistic regression and subgroup analyses, adjusted for various covariates, were performed to investigate the relationship between LAP and the prevalence of SUI in adult women. Additionally, mediation analysis was conducted to evaluate the contributions of oxidative stress and inflammatory factors to this association.
resultsThe prevalence of SUI among women in the United States was 46.02%. After adjustment for confounding factors, the odds ratio for LAP and SUI was 1.003 (95% confidence interval, 1.001-1.004; P=0.002), indicating a positive association. Gamma-glutamyl transferase mediated this relationship, explaining 40.0% of the effect (P=0.036).
conclusionThis study's findings indicate a positive association between LAP and the prevalence of SUI in women, with oxidative stress potentially acting as a mediator in this relationship.
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