Evidence map›Paper›PMID 40635411›Full record

ArticleAnnals of medicine2025

Optimal threshold of time interval from symptom onset to diagnosis for identification of severity and outcomes in acute symptomatic pulmonary embolism.

Wei Xiong, Qiangqiang Qin, Xiaoyang Song, Zhenzhong Deng, Mei Xu, Dongmei Wang, Qihuan Yao, Jianmin Qu, Yong Luo, Fengfeng Han

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Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Wei XiongDepartment of Pulmonary and Critical Care Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID 0000-0003-2126-8535
Qiangqiang QinDepartment of Pulmonary and Critical Care Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Xiaoyang SongDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Zhenzhong DengDepartment of Oncology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Mei XuDepartment of General Practice, North Bund Community Health Service Center, Hongkou District, Shanghai, China.
Dongmei WangDepartment of Pulmonary and Critical Care Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Qihuan YaoDepartment of Traditional Chinese Medicine, Kongjiang Hospital, Yangpu District, Shanghai, China.
Jianmin QuDepartment of Critical Care Medicine, Tongxiang First People's Hospital, Tongxiang, China.ORCID 0000-0003-0551-6893
Yong LuoDepartment of Pulmonary and Critical Care Medicine, Chongming Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Fengfeng HanDepartment of Pulmonary and Critical Care Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe more severe the pulmonary embolism (PE), the shorter the time interval from PE symptom onset to diagnosis (OTD). Nevertheless, it is not known how many days of OTD is the optimal threshold for the identification of severe PE or what differences exist in outcomes among PE patients classified by this threshold.

methodsPatients with acute symptomatic PE were retrospectively studied to determine the optimal OTD threshold for identifying the severity and outcomes of PE. The differences in one-year mortality, VTE recurrence, major bleeding, and composite outcomes among patients with PE classified by this threshold were compared.

resultsA total of 1878 patients with PE were finally obtained. All patients were divided into the short OTD (OTD ≤ 1day) group (

conclusionsPE patients with OTD ≤ 1day had more high-risk PE and worse one-year clinical outcomes, compared to those with OTD > 1day. An OTD of one day could be the optimal threshold for the identification of severity and outcomes of PE.

Indexed as

Pulmonary EmbolismAcute DiseaseAgedFemaleHemorrhageHumansMaleMiddle AgedRecurrenceRetrospective StudiesSeverity of Illness IndexTime Factorsidentificationonset to diagnosisoutcomesPulmonary embolismseveritysymptom

Identifiers

PMID40635411
PMCPMC12247100

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