ArticlePhysiological reports2025
Muscle afferent ASIC3 upregulation mediates the exacerbated exercise pressor reflex in male rats following hindlimb ischemia-reperfusion.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Myophosphorylase Knock Out Prevents the Exaggerated Exercise Pressor Reflex in Rats With Simulated Peripheral Artery Disease.Acta physiologica (Oxford, England) · 2026Article
- Muscle afferent ASIC3 upregulation mediates the exacerbated exercise pressor reflex in male rats following hindlimb ischemia-reperfusion.Physiological reports · 2025Article
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Authors and funding
3 authors.
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Abstract
We examined if the hindlimb muscle ischemia-reperfusion (IR) alters ASIC3-mediated muscle afferent activity in regulating the exercise pressor reflex (EPR). APETx2 (an ASIC3 antagonist) was arterially injected into the hindlimb before static muscle contraction. The mean arterial pressure (MAP) and heart rate (HR) were recorded. ASIC3-mediated MAP response was studied via intra-arterially injected lactic acid (LA). Western blot and immunofluorescence were used to determine the ASIC3 expression and location in L4-6 dorsal root ganglion (DRG). Calcium imaging was applied to detect pH6.7-induced Ca
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