Evidence map›Paper›PMID 40635369›Full record

ArticleMolecular plant pathology2025

Cytokinesis-Defective 1 (CYT1) Positively Regulates Plant Antiviral Immunity by Promoting Callose Deposition and Ascorbic Acid Biosynthesis.

Xue Jiang, Yuting Wang, Yu Zhao, Xayvangye Korxeelor, Wenqian Fan, Xinyue Fan, Yong Li, Xiaoxia Wu, Xueping Zhou, Fangfang Li and 3 more

Erratum issuedAbstract read
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In one paragraph

Article in Molecular plant pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Xue JiangCollege of Plant Protection, Northeast Agricultural University, Harbin, Heilongjiang, China.
Yuting WangCollege of Plant Protection, Northeast Agricultural University, Harbin, Heilongjiang, China.
Yu ZhaoCollege of Plant Protection, Northeast Agricultural University, Harbin, Heilongjiang, China.
Xayvangye KorxeelorCollege of Plant Protection, Northeast Agricultural University, Harbin, Heilongjiang, China.
Wenqian FanCollege of Plant Protection, Northeast Agricultural University, Harbin, Heilongjiang, China.
Xinyue FanCollege of Plant Protection, Northeast Agricultural University, Harbin, Heilongjiang, China.
Yong LiSchool of Life Science, Northeast Agricultural University, Harbin, Heilongjiang, China.
Xiaoxia WuCollege of Agriculture, Northeast Agricultural University, Harbin, Heilongjiang, China.
Xueping ZhouState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID 0000-0001-5311-7331
Fangfang LiState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.
Xiaoyun WuCollege of Plant Protection, Northeast Agricultural University, Harbin, Heilongjiang, China.
Weiqin JiCollege of Plant Protection, Northeast Agricultural University, Harbin, Heilongjiang, China.
Xiaofei ChengCollege of Plant Protection, Northeast Agricultural University, Harbin, Heilongjiang, China.ORCID 0000-0002-9771-9059

Funding

Basic Research Project for Outstanding Young Teacher of Heilongjiang Province YQJH2023186Heilongjiang Provincial Natural Science Foundation of China TD2022C003National Key Research and Development Program of China 2023YFD1700701
6 · The paper itself

Abstract

NUCLEAR INCLUSION B (NIb), the RNA-dependent RNA polymerase (RdRp) of potyviruses, plays a critical role in both viral replication and suppression of host antiviral immunity. However, the mechanisms by which NIb suppresses host immunity remain poorly understood. In this study, we used affinity purification-mass spectrometry to identify host factors interacting with NIb encoded by turnip mosaic virus (TuMV). We identified 57 potential NIb-interacting host factors, including mannose-1-phosphate guanylyltransferase CYTOKINESIS-DEFECTIVE 1 (CYT1). Virus infectivity assays showed that TuMV infection was significantly attenuated in Nicotiana benthamiana leaves transiently expressing CYT1 and in transgenic Arabidopsis overexpressing CYT1. Exogenous application of ascorbic acid (AsA) and inhibition of N-linked glycosylation reduced virus infection. Furthermore, overexpression of CYT1 induced callose deposition, and inhibition of callose synthesis enhanced virus infection. We also demonstrated that NIb interacts with the C-terminal domain of CYT1, affects its cytosolic distribution, and inhibits AsA accumulation. These findings suggest that CYT1 positively regulates plant antiviral immunity by promoting callose deposition and ascorbic acid biosynthesis.

Indexed as

Arabidopsis ProteinsAscorbic AcidGlucansNucleotidyltransferasesPlant ImmunityArabidopsisNicotianaPlant DiseasesPlants, Genetically ModifiedPotyvirusArabidopsis ProteinsAscorbic AcidcalloseGlucansmannose 1-phosphate guanylyltransferaseNucleotidyltransferasesascorbic acidcalloseCYT1NIbTuMV

Identifiers

PMID40635369
PMCPMC12241708

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.