Evidence map›Paper›PMID 40635271›Full record

ArticleAdvanced healthcare materials2025

Glyco Ionic Liquids as Novel Nanoparticle Coatings to Enhance Triple-Negative Breast Cancer Drug Delivery.

Gaya S Dasanayake, Christine M Hamadani, Fikir Hailu, Iyanuoluwani Owolabi, Mira Patel, Claylee M Chism, Veeresh Toragall, Sandeep K Misra, Sushil K Mishra, Mohamed E Jahan and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Gaya S DasanayakeDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.
Christine M HamadaniDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.
Fikir HailuDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.
Iyanuoluwani OwolabiSchool of Biological, Environmental, Earth Sciences (BEES), University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Mira PatelDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.
Claylee M ChismDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.
Veeresh ToragallDepartment of Biomedical Engineering, University of Mississippi, University, MS, 38677, USA.
Sandeep K MisraDepartment of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
Sushil K MishraDepartment of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
Mohamed E JahanDepartment of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
Priyavrat VashisthDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.
Joshua S SharpDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.
Alex FlyntSchool of Biological, Environmental, Earth Sciences (BEES), University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Robert J DoerksenDepartment of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
Thomas A WerfelDepartment of Biomedical Engineering, University of Mississippi, University, MS, 38677, USA.
Gagandeep SinghDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.
Eden E L TannerDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.ORCID https://orcid.org/0000-0002-7919-2249

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
Tracking Glycosylation State with Fluorinated Glycosides ProbesP20GM130460 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Joshua S Sharp · 2020 to 2026
$17.9M
Validation of the Regulatory Potential of Tailed MirtronsR15GM120716 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI FLYNT, ALEX · 2016 to 2016
$437k
NIGMS NIH HHS P20 GM103476NIGMS NIH HHS P20 GM130460NIGMS NIH HHS R15 GM120716NIH HHS P20GM103476NIH HHS P20GM130460
6 · The paper itself

Abstract

Targeted drug delivery seeks to revolutionize disease treatment by enhancing therapeutic efficacy and specificity. However, developing and achieving precisely targeted delivery remains a significant challenge, particularly in cancers such as triple-negative breast cancer (TNBC), which lack traditional markers for targeted delivery. TNBC cells overexpress glucose transport proteins (GLUTs) on their surfaces, providing an opportunity for targeting. Herein, sugar-based ionic liquids (Glyco-ILs or GILs) are developed and used to modify poly (lactic-co-glycolic acid) (PLGA) nanocarriers (NPs), show enhanced affinity and selectivity towards TNBC cells and human and mouse erythrocytes. Inhibition assays, molecular docking simulations, and liquid chromatography-mass spectrometry (LCMS) analysis data show that the enhanced nanoparticle affinity for TNBC cells is likely due to a combination of specific binding interactions with GLUT transporters and endocytosis. The observed RBC affinity is evidenced to be driven by interactions with RBC membrane GLUTs along with their unique serum protein corona on the nanoparticle surface. In vivo, experiments in a healthy BALB/c mouse model show that Glyco-IL-NPs demonstrate longer retention time in the bloodstream and a significant reduction in liver accumulation relative to the control. These findings suggest that Glyco-IL-modified PLGA nanoparticles (GIL-NPs) hold a promising approach for selective drug delivery, particularly in cells that overexpress GLUTs.

Indexed as

Drug Delivery SystemsIonic LiquidsNanoparticlesTriple Negative Breast NeoplasmsAnimalsCell Line, TumorDoxorubicinDrug CarriersErythrocytesFemaleHumansMiceMice, Inbred BALB CPolylactic Acid-Polyglycolic Acid CopolymerDoxorubicinDrug CarriersIonic LiquidsPolylactic Acid-Polyglycolic Acid CopolymerGlyco scienceionic liquidsnanoparticlestriple‐negative breast cancer

Identifiers

PMID40635271
PMCPMC12270336

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.