Evidence map›Paper›PMID 40635115›Full record

ArticleGlobal health research and policy2025

Early-life undernutrition increases the risk of death from chronic diseases in adulthood: a population-based cohort study.

Mengqiu Wu, Hongrui Tian, Chuanhai Guo, Zhen Liu, Yaqi Pan, Fangfang Liu, Ying Liu, Wenlei Yang, Huanyu Chen, Zhe Hu and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global health research and policy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01688908 (Effcacy of Endoscopic Screening for Esophageal Cancer in China), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01688908 naactive not recruitingnot on this map

Effcacy of Endoscopic Screening for Esophageal Cancer in China (ESECC): a Population-based Randomized Controlled Trial

TypeinterventionalSponsorPeking UniversityRan2012 to 2027Enrolled33,948ConditionsEsophageal Squamous Cell Carcinoma, DysplasiaArmsEndoscopic Screening
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mengqiu Wu *Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genetics, Peking University Cancer Hospital and Institute, #52 Fucheng Rd, Beijing, 100142, China.
Hongrui Tian *Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genetics, Peking University Cancer Hospital and Institute, #52 Fucheng Rd, Beijing, 100142, China.
Chuanhai GuoKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genetics, Peking University Cancer Hospital and Institute, #52 Fucheng Rd, Beijing, 100142, China.
Zhen LiuKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genetics, Peking University Cancer Hospital and Institute, #52 Fucheng Rd, Beijing, 100142, China.
Yaqi PanKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genetics, Peking University Cancer Hospital and Institute, #52 Fucheng Rd, Beijing, 100142, China.
Fangfang LiuKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genetics, Peking University Cancer Hospital and Institute, #52 Fucheng Rd, Beijing, 100142, China.
Ying LiuKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genetics, Peking University Cancer Hospital and Institute, #52 Fucheng Rd, Beijing, 100142, China.
Wenlei YangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genetics, Peking University Cancer Hospital and Institute, #52 Fucheng Rd, Beijing, 100142, China.
Huanyu ChenKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genetics, Peking University Cancer Hospital and Institute, #52 Fucheng Rd, Beijing, 100142, China.
Zhe HuKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genetics, Peking University Cancer Hospital and Institute, #52 Fucheng Rd, Beijing, 100142, China.
Mengfei LiuKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genetics, Peking University Cancer Hospital and Institute, #52 Fucheng Rd, Beijing, 100142, China. liumengfei@hsc.pku.edu.cn.
Zhonghu HeState Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Genetics, Peking University Cancer Hospital and Institute, #52 Fucheng Rd, Beijing, 100142, China. zhonghuhe@foxmail.com.
Yang KeState Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Genetics, Peking University Cancer Hospital and Institute, #52 Fucheng Rd, Beijing, 100142, China. keyang@bjmu.edu.cn.

Funding

Beijing Natural Science Foundation 7222243National Key R&D Program of China 2021YFC2500405
6 · The paper itself

Abstract

backgroundEarly-life undernutrition, particularly during critical developmental periods, may have lasting impacts on non-communicable diseases (NCDs) in adulthood. The Chinese Great Famine (1959-1961) provides a unique opportunity to evaluate these effects in a large-scale population study. To investigate the impact of early-life undernutrition on adult mortality due to NCDs in individuals exposed to the Chinese Great Famine.

methodsWe analyzed data from a medical insurance database in Hua County, China, including 15,088 individuals born during the famine (1959-1961) and 49,924 individuals deemed unexposed because they were born after the famine (1962-1964), with follow-up from 2012 to 2023. Multivariable Cox regression and competing risks regression were used to assess the association between early-life undernutrition and mortality.

resultsEarly-life undernutrition was associated with increased risks of all-cause mortality (HR

conclusionsThis study demonstrates the long-term adverse effects of early-life undernutrition on NCD mortality in adulthood, underscoring the importance of nutritional interventions during critical developmental periods to reduce the burden of NCDs. CLINICAL

trial registrationEndoscopic Screening for Esophageal Cancer in China (ESECC) randomized controlled trial (Clinical trial: NCT01688908).

Indexed as

FamineMalnutritionNoncommunicable DiseasesAdultAgedChinaChronic DiseaseCohort StudiesFemaleHumansMaleMiddle AgedNeoplasmsRisk FactorsChinese great famineChronic non-communicable diseasesEarly-life undernutritionMortality

Identifiers

PMID40635115
PMCPMC12243173

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.