Evidence map›Paper›PMID 40635059›Full record

ArticleJournal of medical case reports2025

Renal cell carcinoma accompanied by aldosterone-secreting contralateral adrenal metastasis: a case report.

Modar Doyya, Ghina Alloush, Mazen Alloush

Abstract readCase Reports
In one paragraph

Article in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Modar DoyyaFaculty of Medicine, Damascus University, Damascus, Syria. modar2.doyya@damascusuniversity.edu.sy.ORCID http://orcid.org/0009-0007-9330-2030
Ghina AlloushFaculty of Medicine, Damascus University, Damascus, Syria.
Mazen AlloushDepartment of Urology, Al-Assad University Hospital, Damascus, Syria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney cancer is a highly prevalent malignancy, consistently ranking among the top ten cancers affecting both men and women, and its mortality has been increasing globally. Renal cell carcinoma is the most common type and has a tendency to metastasize, with a predilection for spreading to other organs. While the adrenal gland is located adjacent to the kidney, metastasis of renal cell carcinoma to the adrenal gland is considered rare compared with other sites such as the lungs, liver, and bones. In addition, the occurrence of metastasis to the contralateral adrenal gland is an exceedingly rare phenomenon. CASE PRESENTATION: A 57-year-old Arabic female patient presented with intermittent hematuria over a period of several months. The patient's medical and surgical history revealed no significant findings. Laboratory tests revealed normal results, with the exception of elevated aldosterone levels and a high aldosterone renin ratio, despite a normal blood pressure reading. Further investigations revealed the coexistence of renal cell carcinoma and adrenal adenoma on the left side, along with adrenal mass on the right side, which confirmed its metastatic nature after resection and pathological study. As a result, a left nephrectomy and right adrenalectomy were subsequently conducted. Postsurgery, the aldosterone level normalized, confirming the secretory function of the metastasized renal carcinoma in the right adrenal gland.

conclusionThe secretion of aldosterone from an adrenal metastasis arising from renal cell carcinoma is a rare phenomenon that healthcare providers should bear in mind during differential diagnosis. It is imperative to conduct thorough investigations and extended research to understand the potential complications associated with this unique presentation.

Indexed as

Adrenal Gland NeoplasmsAldosteroneCarcinoma, Renal CellKidney NeoplasmsAdrenalectomyFemaleHematuriaHumansMiddle AgedNephrectomyAldosteroneAdrenalAldosteroneCase reportMetastasesRenal cell carcinoma

Identifiers

PMID40635059
PMCPMC12239418

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