SynthesisBMC musculoskeletal disorders2025
Prosthesis survival situation and complications following total hip arthroplasty in hemophilic patients: a systematic review.
Synthesis in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Review of the influence of anaemia on the effect of total hip arthroplasty, and the prognosis of patients: recent advances and future directions.Annals of medicine · 2026Review
- Long-term prosthesis survival of total hip and total knee arthroplasty in people with inherited bleeding disorders.Research and practice in thrombosis and haemostasis · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundHemophilic arthropathy, resulting from recurrent joint bleeding in patients with hemophilia, often necessitates total hip arthroplasty (THA) to alleviate pain and improve joint function. However, the unique challenges posed by hemophilia, including coagulopathy and compromised bone health, result in increased risks of complications such as bleeding, infection, and prosthesis loosening.
methodsA systematic search of PubMed, Cochrane Library, EMBASE, and Web of Science was conducted up to September 2024. Studies reporting prosthesis survival or complications in hemophilia patients undergoing THA were included. Methodological quality was assessed using the Methodological Index for Non-Randomized Studies (MINORS) criteria.
resultsFourteen retrospective cohort studies, encompassing 190 THA cases, were included. A total of 190 THA cases were involved, of which 175 prostheses survived, with aseptic loosening (57%) being the leading cause of failure. Complications included bleeding (34.8%), infections (19.7%), and aseptic loosening (15.1%). Key risk factors included reduced bone mineral density, recurrent hemarthrosis, and immune dysfunction (HIV) due to clotting factor infusions. Strategies such as preoperative optimization of clotting factors and bone quality were highlighted as crucial for improving outcomes.
conclusionsThis paper confirms the findings of previous studies that THA is an effective treatment for advanced-stage haemophilic arthropathy, offering significant pain relief and improved function. However, its high rate of complications has to be reduced with a correct perioperative hemostasis and a good surgical technique. This type of surgery should only be performed in centers specialized in the treatment of haemophilia by a team of surgeons expert in the implantation of hip prostheses.
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