Evidence map›Paper›PMID 40634961›Full record

ArticleBMC complementary medicine and therapies2025

Antimicrobial activity of Salvia spinosa against Enterococcus faecalis causing endodontic infections: an in-vitro, ex-vivo, and in-silico study.

Wedad M Nageeb, Sherouk Hussein Adam, Nihal Ali, Marwa Sharaan

Erratum issuedAbstract read
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In one paragraph

Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Wedad M NageebDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. wedad_saleh@med.suez.edu.eg.ORCID http://orcid.org/0000-0001-9884-9755
Sherouk Hussein AdamDepartment of Endodontics, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.
Nihal AliDirectorate of Health, Suez, Egypt.
Marwa SharaanDepartment of Endodontics, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnterococcus faecalis (E. faecalis) often persists in root canal systems and it is rather unsusceptible to many root canal medications including the standard Calcium Hydroxide treatment which often causes therapeutic failure. Natural herbal alternatives are preferred as new intracanal medications since they are less-toxic, renewable, and are cost-effective. The aim of this work was to assess the effectiveness of Salvia spinosa and its combination with Calcium Hydroxide as intracanal medications for eliminating Enterococcus faecalis in an ex-vivo root canal infection model compared to standard Calcium Hydroxide treatment.

methodsSalvia spinosa methanolic extract was tested using the standard disc diffusion method against Enterococcus faecalis ATCC 19433 and compared to Ca(OH)

resultsS. spinosa extract and its combination with Ca(OH)

conclusionS. spinosa shows promising antimicrobial activity against E. faecalis and thus offers a promising natural alternative approach to treat root canal endodontic infections for further detailed testing and investigation.

Indexed as

Anti-Bacterial AgentsEnterococcus faecalisGram-Positive Bacterial InfectionsPlant ExtractsSalviaCalcium HydroxideDental Pulp CavityHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsCalcium HydroxidePlant ExtractsAntibacterialCalcium hydroxideEndodontic medicationsEnterococcus faecalisHerbal alternativesRoot canal medicationsSalvia spinosa

Identifiers

PMID40634961
PMCPMC12243204

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.