Evidence map›Paper›PMID 40634945›Full record

ArticleGlobalization and health2025

Understanding the political economy of reforming global health initiatives - insights from global and country levels.

Sophie Witter, Natasha Palmer, Rosemary Jouhaud, Shehla Zaidi, Severine Carillon, Rene English, Giulia Loffreda, Emilie Venables, Shifa Salman Habib, Jeff Tan and 9 more

Abstract read
In one paragraph

Article in Globalization and health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  5. Review
  6. Article
  7. Global Health Initiatives and Universal Health Coverage in Pakistan-Aligned for the Future?The International journal of health planning and management · 2026
    Article
  8. Article
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  13. Lenacapavir for HIV Prevention in Africa: Opportunities, Barriers, and Policy Priorities.Journal of the International Association of Providers of AIDS Care
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sophie WitterInstitute for Global Health and Development, Queen Margaret University, Edinburgh, Scotland, UK. switter@qmu.ac.uk.
Natasha PalmerInstitute for Global Health and Development, Queen Margaret University, Edinburgh, Scotland, UK.
Rosemary JouhaudGeneva Centre of Humanitarian Studies, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Shehla ZaidiAga Khan University (International) in the UK, London, UK.
Severine CarillonCheikh Anta Diop University, Dakar, Senegal.
Rene EnglishDivision of Health Systems and Public Health, Department of Global Health, Stellenbosch University, Stellenbosch, South Africa.
Giulia LoffredaInstitute for Global Health and Development, Queen Margaret University, Edinburgh, Scotland, UK.
Emilie VenablesGeneva Centre of Humanitarian Studies, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Shifa Salman HabibAga Khan University Pakistan, Karachi, Pakistan.
Jeff TanAga Khan University (International) in the UK, London, UK.
Fatouma HaneCheikh Anta Diop University, Dakar, Senegal.
Maria Paola BertoneInstitute for Global Health and Development, Queen Margaret University, Edinburgh, Scotland, UK.
Seyed-Moeen HosseinalipourGeneva Centre of Humanitarian Studies, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Valery RiddeCheikh Anta Diop University, Dakar, Senegal.
Asad ShoaibAga Khan University Pakistan, Karachi, Pakistan.
Adama FayeCheikh Anta Diop University, Dakar, Senegal.
Lilian DudleyDivision of Health Systems and Public Health, Department of Global Health, Stellenbosch University, Stellenbosch, South Africa.
Karen DanielsDivision of Health Systems and Public Health, Department of Global Health, Stellenbosch University, Stellenbosch, South Africa.
Karl BlanchetGeneva Centre of Humanitarian Studies, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Funding

Wellcome Trust
6 · The paper itself

Abstract

introductionSince 2000, the number and role of global health initiatives (GHIs) has been growing, with these platforms playing an increasingly important role in pooling and disbursing funds dedicated to specific global health priorities. While recognising their important contribution, there has also been a growth in concerns about distortions and inefficiencies linked to the GHIs and attempts to improve their alignment with country health systems. There is a growing momentum to adjust GHIs to the current broader range of global health threats, such as non-communicable diseases, humanitarian crises and climate change, and against the backdrop of the recent aid cuts. However, reform attempts are challenged by the political economy of the current structures.

methodsIn this article, we draw on research conducted as part of the Future of Global Health Initiatives process. The study adopted a cross-sectional, mixed-methods approach, drawing from a range of data sources and data collection methods, including a global and regional level analysis as well as three embedded country case studies in Pakistan, South Africa and Senegal. All data was collected from February to July 2023. 271 documents were analysed in the course of the study, along with data from 335 key informants and meeting participants in 66 countries and across a range of constituencies. For this paper, data were analysed using a political economy framework which focused on actors, context (especially governance and financing) and framing.

findingsIn relation to actors, the GHIs themselves have become increasingly complex (both internally and in their interrelations with other global health actors and one another). They have a large range of clients (including at national level and amongst multilateral agencies) which function as collaborators as well as competitors. Historically there have been few incentives for any of the actors to maximise collaboration given the competitive funding landscape. Power to exert pressure for reforms sits ultimately with bilateral and private funders, though single-issue northern non-governmental organisations (NGOs) are also cited as important influencers. Funders have not collaborated to enable reforms, despite concerns amongst a number of them, because of the helpful functional role of GHIs, which serves funder interests. Some key global boards are reported to be engineered for stasis, and there are widespread concerns about lack of transparency and over-claiming (by some GHIs) of their results. Framing of narratives about achievements and challenges is important to enable or block reforms and are vigorously contested, with stakeholders often selecting different outcomes to emphasise in justifying positions.

conclusionGHIs have played an important role in the global health ecosystem but despite formal accountability structures to include recipient governments, substantive accountability has been focused upwards to funders, with risk management strategies which prioritise tracking resources more than improved national health system performance. Achieving consensus on reforms will be challenging but current funding pressures and new threats are creating a sense of urgency, which may shift positions. Political economy analysis can model and influence these debates.

Indexed as

Global HealthHealth Care ReformPoliticsCross-Sectional StudiesHumansFinancingGlobal health initiativesGovernancePakistanPolitical economy analysisSenegalSouth Africa

Identifiers

PMID40634945
PMCPMC12243378

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.