Evidence map›Paper›PMID 40634933›Full record

ArticleBMC oral health2025

Genotoxic and cytotoxic effects of cone beam computed tomography on exfoliated epithelial cells in different age groups.

Maged Bakr, Fatma Ata, Asmaa Saleh Elmahdy, Bassant Mowafey

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maged BakrDepartment of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dentistry, Mansoura University, El- gomhouria Street, P.O. Box: 35516, Mansoura City, Dakahlia, Egypt.
Fatma AtaDepartment of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dentistry, Mansoura University, El- gomhouria Street, P.O. Box: 35516, Mansoura City, Dakahlia, Egypt.
Asmaa Saleh ElmahdyDepartment of Oral Biology Faculty of Dentistry, Mansoura University, 60 El-gomhouria Street, P.O. Box: 35516, Mansoura City, Dakahlia, Egypt.
Bassant MowafeyDepartment of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dentistry, Mansoura University, El- gomhouria Street, P.O. Box: 35516, Mansoura City, Dakahlia, Egypt. dr-bassantmowafey@mans.edu.eg.ORCID http://orcid.org/0000-0001-8539-0594

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiographic examination is an essential method for dental practitioners. Cone beam computed tomography (CBCT) is considered a common radiographic technique for dental problems. However, there are serious concerns regarding the biological effects of radiation, particularly at a young age. The objective of the present study was to evaluate the cytotoxic and genotoxic effects of cone beam computed tomography on the exfoliated buccal epithelial cells in two distinct age groups.

methodsForty patients were included in the current study. They were divided into two groups: group I included patients ≥ 18 years old, and group II included those ˂18 years old. They experienced CBCT as part of a diagnostic procedure. Cells were collected before CBCT exposure and 10-12 days after CBCT exposure. The Papanicolaou method was utilized to stain cytological smears. Micronuclei count and cytotoxic cellular alterations (Karyolysis, Pyknosis, and Karyorrhexis) were assessed. The Mann-Whitney U test was used to compare the two studied groups for non-normally distributed data. A two-way ANOVA test was used to study the combined effect of two independent factors on dependent continuous outcomes.

resultsIn groups I and II, there were statistically significant differences in micronucleus counts and cytological changes before and after CBCT exposure. There were no statistically significant differences between the two groups in micronucleus counts and cytological changes after CBCT exposure.

conclusionsCBCT induces genotoxic and cytotoxic effects in both age groups, with cytotoxicity more evident in younger patients. Therefore, clinical justification is required before using CBCT.

Indexed as

Cone-Beam Computed TomographyEpithelial CellsMouth MucosaAdolescentAdultAge FactorsFemaleHumansMaleMicronucleus TestsMiddle AgedYoung AdultBuccal mucosaCone beam computed tomographyCytological changesMicronucleus

Identifiers

PMID40634933
PMCPMC12243335

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