Evidence map›Paper›PMID 40634929›Full record

ArticleBMC oral health2025

Developing a novel therapeutic and bioactive resin-based root canal sealer incorporated with silver polydopamine-modified hydroxyapatite fillers.

Samar M Nashaat, Enas T Enan, Ahmed S G Srag El-Din, Dina Abdelaziz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samar M NashaatDepartment of Dental Biomaterials, Faculty of Dentistry, Mansoura University, 35516, Mansoura, Egypt.
Enas T EnanDepartment of Dental Biomaterials, Faculty of Dentistry, Mansoura University, 35516, Mansoura, Egypt.
Ahmed S G Srag El-DinDepartment of Pharmaceutics, College of Pharmacy, Almaaqal University, Basrah, 61014, Iraq.
Dina AbdelazizDepartment of Dental Biomaterials, Faculty of Dentistry, Mansoura University, 35516, Mansoura, Egypt. dina_a_aziz@mans.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResidual root canal microbiota in the inaccessible areas of the root canal despite cleaning and shaping and the adverse effects of the various root canal irrigants on dentin mineral content pose a major challenge to successful root canal therapy. The aim of this study was to develop therapeutic and bioactive resin-based root canal sealer (RCS) with good wetting ability.

methodsSilver polydopamine-modified hydroxyapatite (HA-PDA-Ag-PDA) fillers were synthesized. Hydroxyapatite particles were analyzed using X-ray diffraction (XRD), while the final prepared fillers were characterized by Fourier transform infrared (FT-IR) spectroscopy and transmission electron microscopy (TEM). The resin-based RCS (Adseal

resultsXRD, FT-IR, TEM characterizations confirmed the successful synthesis of the HA-PDA-Ag-PDA fillers. Modified RCS showed strong bacterial inhibition effect against E. faecalis with insignificant difference between G1 and G2. Modified RCS (G1 and G2) also showed good mineralization potential and improvement in wettability of dentin surface.

conclusionsHA-PDA-Ag-PDA fillers significantly improved the antibacterial, mineralization properties as well as the wetting ability of resin-based RCS.

Indexed as

DurapatiteIndolesPolymersRoot Canal Filling MaterialsSilverAnti-Bacterial AgentsHumansMaterials TestingMicroscopy, Electron, TransmissionSpectroscopy, Fourier Transform InfraredWettabilityX-Ray DiffractionAnti-Bacterial AgentsDurapatiteIndolespolydopaminePolymersRoot Canal Filling MaterialsSilverAntibacterialHydroxyapatitePolydopamineRemineralizationRoot canal sealerSilver nanoparticlesWettability

Identifiers

PMID40634929
PMCPMC12243216

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.