Evidence map›Paper›PMID 40634890›Full record

ArticleBMC pediatrics2025

Allergen sensitization patterns in children with allergic rhinitis: insights from a four-year retrospective study in Shenzhen, China.

Zhimin Zhao, Liwen Chen, Congfu Huang, Zhuyan Huang, Xiuju Liu, Bo Hu, Zhenwen Zhou

Abstract read
In one paragraph

Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhimin Zhao *Department of Laboratory Medicine, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College), No.6, Ailong Road, Longgang District, Shenzhen, Guangdong, 518172, China.
Liwen Chen *Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.
Congfu HuangDepartment of Pediatrics, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College), Shenzhen, Guangdong, 518172, China.
Zhuyan HuangDepartment of Laboratory Medicine, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College), No.6, Ailong Road, Longgang District, Shenzhen, Guangdong, 518172, China.
Xiuju LiuDepartment of Laboratory Medicine, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College), No.6, Ailong Road, Longgang District, Shenzhen, Guangdong, 518172, China.
Bo HuDepartment of Laboratory Medicine, the Third Affiliated Hospital, Sun Yat-Sen University, Tianhe Road 600#, Guangzhou, Guangdong, 510630, China. hubo@mail.sysu.edu.cn.
Zhenwen ZhouDepartment of Laboratory Medicine, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College), No.6, Ailong Road, Longgang District, Shenzhen, Guangdong, 518172, China. zzw6248@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo characterize allergen sensitization profiles in children with allergic rhinitis (AR) in Shenzhen, China, and assess the influence of demographic, seasonality, and comorbidities factors.

methodsThis retrospective cross-sectional study included 4,279 children diagnosed with AR between April 2020 and March 2024. Serum-specific IgE against 28 common allergens was measured by immunoblotting. Sensitization was defined as sIgE ≥ 0.35 IU/mL. Data were analyzed by age, sex, season, and comorbidities using chi-square tests (P < 0.05).

resultsSensitization to inhaled allergens (78.3%) was more prevalent than to food allergens (65.4%, P < 0.05). Dust mites (61.6%), dog dander (21.8%), and cat dander (11.4%) were the most common inhaled allergens, while milk (46.9%) and egg white (27.4%) were the leading food allergens. Sensitization to inhaled allergens increased with age, while food allergen sensitization decreased (P < 0.05). Boys exhibited higher rates of sensitization to certain allergens, and pronounced seasonal trends were observed, particularly for pollen and shellfish in summer. Children with digestive comorbidities showed broader sensitization across multiple allergens.

conclusionDistinct allergen sensitization patterns in Shenzhen children with AR highlight the need for region-specific diagnostic panels and integrated care, supporting more personalized management and future research directions.

Indexed as

AllergensRhinitis, AllergicAdolescentChildChild, PreschoolChinaCross-Sectional StudiesFemaleFood HypersensitivityHumansImmunoglobulin EInfantMaleRetrospective StudiesSeasonsAllergensImmunoglobulin EAllergen profileAllergic rhinitisChildrenChinaFood allergenInhaled allergenPediatric

Identifiers

PMID40634890
PMCPMC12243126

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.