ArticleBMC cardiovascular disorders2025
Echocardiographic diagnosis of interarterial AAOCA in children: a framework integrating anatomical landmarks and systolic dysfunction for risk assessment.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Coronary Artery Anomalies and Anatomical Variants: Cross-Sectional Diagnostic Imaging and Clinical Background.Journal of imaging · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundAnomalous aortic origin of coronary arteries (AAOCA) with interarterial course poses life-threatening risks in pediatric patients, yet standardized preoperative imaging protocols remain limited. This study aims to establish a systematic echocardiographic framework for AAOCA diagnosis.
methodsA Retrospective Analysis of Ultrasound Images in 11 Cases of AAOCA with Interarterial Course. Among them, 8 cases presented abnormalities with the right coronary artery originating from the left coronary sinus (Anomalous Right Coronary Artery, ARCA), while 3 cases exhibited abnormalities with the left coronary artery originating from the right coronary sinus (Anomalous Left Coronary Artery, ALCA). The ultrasound features are summarized, and left ventricular ejection fraction (LVEF) and segmental wall motion were quantitatively assessed via Simpson’s method.
resultsFour distinct echocardiographic features were identified: (i) Ostial deviation: ARCA at 1–3 o’clock, ALCA at 11 − 1 o’clock (10/11 definitive, 1/11 suspected); (ii) Acute angle: Mean angle 43°±8° vs. normal 90°±5° (P < 0.001); (iii) Parallel course sign: All cases exhibited proximal coronary adherence to the aortic wall (Fig. 2); (iv) Diastolic flow acceleration: Detected in intramural/stenotic segments (peak velocity > 50 cm/s; Fig. 3). Prior to surgery, the 11 cases of AAOCA exhibited varying degrees of symptoms such as chest tightness, chest pain, and even syncope. ARCA (median 64.1%, IQR 62.3–67.4%) versus severely reduced in ALCA (median 39.2%, IQR 33.8–43.6%; P < 0.001, Mann-Whitney U test), with ALCA cases showing more extensive wall motion abnormalities (3/3 vs. 2/8; P = 0.048). Postoperatively, 10/11 cases achieved normal cardiac function.
conclusionsEchocardiography provides a clinically actionable protocol for preoperative AAOCA diagnosis by integrating anatomical markers (Acute deviation, parallel course) and functional metrics (LVEF, wall motion). This approach enables early identification of high-risk cases (e.g., ALCA with severe systolic dysfunction) and guides timely intervention, reducing reliance on radiation-based imaging in children. Despite limited sample size, the proposed framework addresses a critical gap in pediatric-specific AAOCA management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.