ArticleNature medicine2025
Plasma proteomics links brain and immune system aging with healthspan and longevity.
Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
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Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Liquid biopsy proteomics in ophthalmology : A clinical and scientific perspective].Die Ophthalmologie · 2026Pooled it
- Immunotherapy with a short-lived anti-PD-L1 antibody in Alzheimer's disease: a phase 1b, randomized, double-blind trial.Nature medicine · 2026Trial
- Dynamic lysine acetylation and succinylation of platelet proteins regulates platelet storage lesion: mechanistic insights from multi-omics.Annals of medicine · 2026Article
- A Deep-Learning Based Biomarker of Systemic Cellular Senescence Burden to Predict Mortality and Health Outcomes.Aging cell · 2026Article
- Evaluating the neurofilament light chain-derived gap between biological and chronological age in multiple sclerosis and controls.Journal of neurology · 2026Article
- Blood proteomics of menopause map to brain aging and dementia risk.Nature medicine · 2026Article
- Unlocking Sensitive Data with SPHERE in the Age of AI.bioRxiv : the preprint server for biology · 2026Article
- Association Between Menopausal Hormone Therapy and Alzheimer Disease Neuropathology.Neurology · 2026Article
- Structural decomposition enables multi-omics dissection of common and organ-specific aging.Science China. Life sciences · 2026Article
- Combating ageing beyond the cell: Emerging roles of extracellular proteostasis.The FEBS journal · 2026Review
- Translating cellular aging clocks into disease risk prediction.Cell reports. Medicine · 2026Article
- A machine learning-derived dietary pattern for aging.NPJ science of food · 2026Article
- Proteomic organ-specific signatures, ageing traits, disease risks and genetic architecture in an East Asian population.EBioMedicine · 2026Article
- Construction and Validation of Plasma Protein-Based Musculoskeletal Biological Age and Genetic and Environmental Risk Profiles.Aging cell · 2026Article
- Early life sugar rationing and ageing related diseases, biological ageing and mortality.Nature communications · 2026Article
- Metabolism Pathway Blood Proteomic Differences in Lewy Body Dementia Compared to Alzheimer's Disease.International journal of molecular sciences · 2026Article
- The OmniAge compendium of aging omic biomarkers links mitotic clocks to clonal hematopoiesis and causality.Nature communications · 2026Article
- Longitudinal plasma proteomics separates diagnostic differences from progression-linked changes in Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
- ProMeta: a meta-learning framework for robust disease diagnosis and prediction from plasma proteomics.Bioinformatics (Oxford, England) · 2026Article
- Article
12 more citing papers are in PubMed but not listed here.
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12 authors.
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Abstract
Plasma proteins derived from specific organs can estimate organ age and mortality, but their sensitivity to environmental factors and their robustness in forecasting onset of organ diseases and mortality remain unclear. To address this gap, we estimate the biological age of 11 organs using plasma proteomics data (2,916 proteins) from 44,498 individuals in the UK Biobank. Organ age estimates were sensitive to lifestyle factors and medications and were associated with future onset (within 17 years' follow-up) of a range of diseases, including heart failure, chronic obstructive pulmonary disease, type 2 diabetes and Alzheimer's disease. Notably, having an especially aged brain posed a risk of Alzheimer's disease (hazard ratio (HR) = 3.1) that was similar to carrying one copy of APOE4, the strongest genetic risk factor for sporadic Alzheimer's disease, whereas a youthful brain (HR = 0.26) provided protection that was similar to carrying two copies of APOE2, independent of APOE genotype. Accrual of aged organs progressively increased mortality risk (2-4 aged organs, HR = 2.3; 5-7 aged organs, HR = 4.5; 8+ aged organs, HR = 8.3), whereas youthful brains and immune systems were uniquely associated with longevity (youthful brain, HR = 0.60 for mortality risk; youthful immune system, HR = 0.58; youthful both, HR = 0.44). Altogether, these findings support the use of plasma proteins for monitoring of organ health and point to the brain and immune systems as key targets for longevity interventions.
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