Evidence map›Paper›PMID 40634715›Full record

ArticleEJNMMI radiopharmacy and chemistry2025

Jona Wilhelm Gerhards, Laura Schäfer, Daniel Kang, Ute Lindauer, Susanne Lütje, Felix Manuel Mottaghy, Tobias Schmidt, Andreas Theodor Josef Vogg

Abstract read
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jona Wilhelm Gerhards *Department of Nuclear Medicine, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074, Aachen, Germany.
Laura Schäfer *Department of Nuclear Medicine, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074, Aachen, Germany. laschaefer@ukaachen.de.
Daniel KangDepartment of Nuclear Medicine, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074, Aachen, Germany.
Ute LindauerTranslational Neurosurgery and Neurobiology, Department of Neurosurgery, RWTH Aachen University Hospital, 52074, Aachen, Germany.
Susanne LütjeDepartment of Nuclear Medicine, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074, Aachen, Germany.
Felix Manuel MottaghyDepartment of Nuclear Medicine, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074, Aachen, Germany.
Tobias Schmidt *Translational Neurosurgery and Neurobiology, Department of Neurosurgery, RWTH Aachen University Hospital, 52074, Aachen, Germany.
Andreas Theodor Josef Vogg *Department of Nuclear Medicine, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074, Aachen, Germany. avogg@ukaachen.de.ORCID http://orcid.org/0000-0003-0696-3978

Funding

Deutsche Forschungsgemeinschaft 331065168
6 · The paper itself

Abstract

backgroundAneurysmal subarachnoid hemorrhage (aSAH) is a distinct type of stroke, primarily caused by the rupture of a brain aneurysm. The underlying mechanisms of aSAH remain incompletely understood, prompting ongoing research in this area. Recent investigations into the perivascular system revealed a distribution disturbance of the dye Alexa Fluor™ 594 during measurements. To further investigate this distribution anomaly, it is proposed to label the dye with a radionuclide for biokinetic tracking in rats by means of positron emission tomography for enhanced imaging and analysis.

resultsThe fluorescent dye Alexa Fluor™ 594 after chelator conjugation was successfully labeled with the positron-emitting radionuclide

conclusionsThis experimental approach successfully yields the desired radiolabeled dye, which is now available for animal studies, potentially offering enhanced insight into the mechanisms of aSAH.

Indexed as

Alexa Fluor™ 594Gallium-68Multimodal imagingNODA-GA-NHS esterPositron emission tomographyStrokeSubarachnoid hemorrhage

Identifiers

PMID40634715
PMCPMC12240878

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.