Evidence map›Paper›PMID 40634609›Full record

ArticleNature2025

Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics.

M Alejandra Tortorici, Annette Choi, Cecily A Gibson, Jimin Lee, Jack T Brown, Cameron Stewart, Anshu Joshi, Sheri Harari, Isabelle Willoughby, Catherine Treichel and 6 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  5. Article
  6. Computational design of an ultrapotent deltacoronavirus miniprotein inhibitor.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

M Alejandra TortoriciDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2260-2577
Annette ChoiDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Cecily A GibsonDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Jimin LeeDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Jack T BrownDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Cameron StewartDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2786-6256
Anshu JoshiDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Sheri HarariBasic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Isabelle WilloughbyDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Catherine TreichelDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Elizabeth M LeafDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Jesse D BloomHoward Hughes Medical Institute, Seattle, WA, USA.ORCID 0000-0003-1267-3408
Neil P KingDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2978-4692
Christine Tait-BurkardThe Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-0471-3230
Gary R WhittakerDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
David VeeslerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dveesler@uw.edu.ORCID 0000-0002-6019-8675

Funding

Centers for Research on Structural Biology of Infectious Diseases: Universal Influenza Vaccine Research75N93022C00036 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI STAKER, BART · 2022 to 2025
$21.7M
Structure-based design of broadly protective coronavirus vaccinesP01AI167966 · NIAID · UNIVERSITY OF WASHINGTON · PI Francois J Villinger · 2022 to 2026
$15.3M
Unraveling the bat humoral immune response against zoonotic viruses to guide the design of next-generation therapeuticsDP1AI158186 · NIAID · UNIVERSITY OF WASHINGTON · PI VEESLER, DAVID · 2020 to 2024
$5.4M
NIAID NIH HHS 75N93022C00036NIAID NIH HHS DP1 AI158186NIAID NIH HHS P01 AI167966
6 · The paper itself

Abstract

The ability of coronaviruses to recombine and cross species barriers affects human and animal health globally and is a pandemic threat

Indexed as

CoronavirusSpike Glycoprotein, CoronavirusVirus InternalizationAnimalsAntibodies, MonoclonalCatsCD13 AntigensCross ReactionsCryoelectron MicroscopyHumansKineticsModels, MolecularPolysaccharidesProtein DomainsReceptors, VirusAntibodies, MonoclonalCD13 AntigensPolysaccharidesReceptors, VirusSpike Glycoprotein, Coronavirus

Identifiers

PMID40634609
PMCPMC12408340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.