ArticleNature2025
How short peptides disassemble tau fibrils in Alzheimer's disease.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Assembling peptides for treating Alzheimer's disease: a supramolecular perspective.RSC advances · 2026Review
- G-Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Engineered neuronal exosomes mediate α-synuclein clearance to ameliorate Parkinson's disease.Journal of nanobiotechnology · 2026Article
- α,β-Dehydroamino-Acid-Containing Peptides Resist Proteolysis and Inhibit Aggregation of a Tau-Derived Model Peptide.The Journal of organic chemistry · 2026Article
- TNMD BRICHOS domain attenuates tau pathology and memory deficits in a mouse model of tauopathy.Cell death & disease · 2026Article
- Innovative D-peptide strategy for targeting tau fibrils in Alzheimer's disease.Science China. Life sciences · 2026Article
- Exercise-conditioned extracellular vesicles in Alzheimer's disease: a multi-organ signaling network linking peripheral adaptation to brain pathology.Frontiers in immunology · 2026Review
- Biomolecular Condensates as Emerging Biomaterials: Functional Mechanisms and Advances in Computational and Experimental Approaches.Advanced materials (Deerfield Beach, Fla.) · 2025Review
Corrections and comments
- Update of
Authors and funding
17 authors.
Ke HouDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA. houkhouk09@gmail.com.ORCID 0000-0003-3869-2076
Peng GeDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-2661-8226
Michael R SawayaDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-0874-9043
Liisa LutterDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Joshua L DolinskyDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-8042-9645
Yuan YangDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-9538-6369
Yi Xiao JiangDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-1433-4952
David R BoyerDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-4487-0230
Xinyi ChengDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-1654-4363
Justin PiDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0009-0000-9956-6351
Jeffrey ZhangDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Jiahui LuDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Romany AbskharonDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Shixin YangJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-9794-7537
Zhiheng YuJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-7114-2570
Juli FeigonDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-3376-435X
David S EisenbergDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA. david@mbi.ucla.edu.ORCID 0000-0003-2432-5419
Funding
The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8MNCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9MTowards Treatment of Alzheimer’s Disease by Targeting Pathogenic Tau and Beta-Amyloid StructuresR01AG070895 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVID EISENBERG · 2022 to 2026
$5.8MStructural biology of telomerase and telomeresR35GM131901 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JULI FEIGON · 2019 to 2026
$5.7MSeeds and Strains Derived from Tau Monomer - Perez Diversity SupplementRF1AG065407 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI DIAMOND, MARC I, JOACHIMIAK, LUKASZ A. · 2020 to 2021
$3.2M800 MHz NMR Console and Cryoprobe ReplacementS10OD025073 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEIGON, JULI · 2018 to 2018
$1.1MBruker Avance III Console and QCI Cryoprobe for a 600 MHz NMR SpectrometerS10OD016336 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLUBB, ROBERT THOMPSON · 2014 to 2014
$600kNIA NIH HHS R01 AG070895NIA NIH HHS RF1 AG065407NIGMS NIH HHS R35 GM131901NIGMS NIH HHS U24 GM129539NIGMS NIH HHS U24 GM129541NIH HHS S10 OD016336NIH HHS S10 OD025073
Abstract
Reducing fibrous aggregates of the protein tau is a possible strategy for halting the progression of Alzheimer's disease (AD)
Indexed as
Alzheimer DiseaseAmyloidPeptidestau ProteinsBrainHumansHydrogen BondingModels, MolecularAmyloidPeptidestau Proteins
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.