Evidence map›Paper›PMID 40634602›Full record

ArticleNature2025

Selective remodelling of the adipose niche in obesity and weight loss.

Antonio M A Miranda, Liam McAllan, Guianfranco Mazzei, Ivan Andrew, Iona Davies, Meryem Ertugrul, Julia Kenkre, Hiromi Kudo, Joana Carrelha, Bhavik Patel and 28 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Article
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  4. Review
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  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Adipogenesis Under Leptin Control: Mechanisms and Model-Specific Effects.International journal of molecular sciences · 2026
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Antonio M A MirandaInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.ORCID 0000-0003-4281-614X
Liam McAllanInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Guianfranco MazzeiInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Ivan AndrewInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Iona DaviesDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Meryem ErtugrulInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Julia KenkreDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Hiromi KudoSection for Pathology, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
Joana CarrelhaDepartment of Immunology and Inflammation, Imperial College London, London, UK.
Bhavik PatelMRC Laboratory of Medical Sciences, London, UK.
Sophie NewtonInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Weihua ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0001-8279-3611
Alice PollardInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Amy CrossTranslational Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Oliver McCallionTranslational Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Mikyung JangInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Ka Lok ChoiInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Scarlett BrownInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Yasmin RasoolInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Marco AdamoUCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, London, UK.
Mohamed ElkalaawyUCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, London, UK.
Andrew JenkinsonUCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, London, UK.
Borzoueh MohammadiUCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, London, UK.
Majid HashemiUCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, London, UK.
Robert GoldinImperial College Healthcare NHS Trust, London, UK.ORCID 0000-0001-5184-4519
Laurence GameInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Joanna HesterTranslational Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Fadi IssaTranslational Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.ORCID 0000-0002-8279-7732
Dylan G RyanMRC Mitochondrial Biology Unit, Keith Peter's building, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4553-9192
Patricia OrtegaImperial College Healthcare NHS Trust, London, UK.
Ahmed R AhmedImperial College Healthcare NHS Trust, London, UK.
Rachel L BatterhamUCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, London, UK.ORCID 0000-0002-5477-8585
John C ChambersImperial College Healthcare NHS Trust, London, UK.
Jaspal S KoonerImperial College Healthcare NHS Trust, London, UK.ORCID 0000-0003-2086-4837
Damir BaranasicInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.ORCID 0000-0001-5948-0932
Michela NosedaNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-9553-5029
Tricia TanDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0001-5873-3432
William R ScottInstitute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. w.scott@imperial.ac.uk.ORCID 0000-0001-5467-114X

Funding

he National Institute for Health Research Imperial Biomedical Research Centre (BRC, CL-2018-21-501; to W.R.S.) and Diabetes UKMedical Research Council UKWellcome Trust
6 · The paper itself

Abstract

Weight loss significantly improves metabolic and cardiovascular health in people with obesity

Indexed as

Adipose TissueObesityWeight LossAdipocytesAdultAnimalsCellular SenescenceFemaleHumansMacrophagesMaleMiceMiddle Aged

Identifiers

PMID40634602
PMCPMC12367556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.