ArticleScientific reports2025
Anti-biofilm peptides can rescue fluconazole and amphotericin B efficacies against Candida albicans.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Morphotype-specific susceptibility toMicrobiology spectrum · 2026Article
- The Antimicrobial Peptide C14R Is Active Against All Pathogenic Species of the ESKAPE Group.Antibiotics (Basel, Switzerland) · 2026Article
- Phage Display-Derived Peptides Have Neutralizing Activities Against Biofilm Formation byPharmaceuticals (Basel, Switzerland) · 2026Article
- Molecular mechanisms, pathogenesis and therapeutic advances ofFrontiers in cellular and infection microbiology · 2026Review
- Biofilm-Associated Candidiasis: Pathogenesis, Prevalence, Challenges and Therapeutic Options.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Antimicrobial Activity of the Peptide C14R Against Ab Initio Growing and Preformed Biofilms ofBiomolecules · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida albicans infections are a global health thread and challenge healthcare environments due to acquired resistances against prominent antifungals like amphotericin B and fluconazole, which additionally have severe adverse effects. The peptide Pom-1 originally isolated from the freshwater mollusk Pomacea poeyana, and its derivatives Pom-1 A-F have proven their potential against biofilms of clinical C. albicans isolates and were suspected to act without candidolytic pore-formation. Here, Pom-1 and its derivatives were shown to act as neutralizing antimicrobial peptides (nAMPs) inhibiting cell-cell interactions and hence biofilm formation. Combining Pom-1 nAMPs with fluconazole and amphotericin B restored their efficacy against resistant C. albicans isolates. Addition of Pom-1 nAMPs allowed to reduce required concentrations to 10-50% below their described effective therapeutic doses. This opens doors not only to mitigate adverse effects of fluconazole and amphotericin B therapies, but also towards novel combination therapies against C. albicans as a severe re-emerging pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.