Evidence map›Paper›PMID 40634426›Full record

ArticleScientific reports2025

Diagnosing facial synkinesis using artificial intelligence to advance facial palsy care.

Leonard Knoedler, Christian Festbaum, Jillian Dean, Helena Baecher, Grégoire de Lambertye, Maximilian Maul, Thomas Schaschinger, Tobias Niederegger, Alexandra Scheiflinger, Michael Alfertshofer and 6 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Leonard KnoedlerDepartment of Oral and Maxillofacial Surgery, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany. leonard.knoedler@charite.de.
Christian FestbaumDepartment of Plastic, Hand and Reconstructive Surgery, Hospital Ingolstadt, Ingolstadt, Germany.
Jillian DeanSchool of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Helena BaecherDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Grégoire de LambertyeDepartment of Informatics, Vienna Technical University, Vienna, Austria.
Maximilian MaulDepartment of Informatics, Vienna Technical University, Vienna, Austria.
Thomas SchaschingerDepartment of Oral and Maxillofacial Surgery, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany.
Tobias NiedereggerDepartment of Oral and Maxillofacial Surgery, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany.
Alexandra ScheiflingerDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Michael AlfertshoferDepartment of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.
Khalil SherwaniMedical University of Vienna, Vienna, Austria.
Claudius SteffenDepartment of Oral and Maxillofacial Surgery, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany.
Max HeilandDepartment of Oral and Maxillofacial Surgery, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany.
Steffen KoerdtDepartment of Oral and Maxillofacial Surgery, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, Germany.
Samuel KnoedlerDepartment of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.
Andreas KehrerDepartment of Plastic, Hand and Reconstructive Surgery, Hospital Ingolstadt, Ingolstadt, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Facial palsy (FP) can lead to significant psychological and physical burdens such as facial synkinesis. This involuntary simultaneous movement of facial musculature remains challenging to diagnose and treat. This study aimed to develop a cost-effective, rapid, and accurate artificial intelligence (AI)-based algorithm to screen FP patients for facial synkinesis. Data from 70 FP patients were collected at the University Hospital Regensburg and compared to healthy controls from an online platform. The standardized patient image series included 9 images, of which 3 were used to train the algorithm. The control images were single images. A total of 385 images were used to train and evaluate a convolutional neural network (CNN). The dataset was divided into training (285 images), validation (29 images), and test sets (71 images). The model was trained over 18 epochs. A web application was developed for practical use. The model achieved an accuracy of 98.6% on the test set, correctly identifying 31 of 32 synkinesis cases and all 39 images of healthy individuals. Performance metrics included an F1-score of 98.4%, precision of 100%, and recall of 96.9%. The web application allowed for image upload and rapid synkinesis prediction. The CNN-based model demonstrated high accuracy in detecting synkinesis in FP patients, offering potential for improved diagnostic accuracy and expedited treatment. Further validation with larger datasets is necessary to ensure robustness and generalizability.

Indexed as

Artificial IntelligenceFacial ParalysisSynkinesisAdultAlgorithmsFemaleHumansMaleMiddle AgedNeural Networks, ComputerYoung AdultAIArtificial intelligenceConvolutional neural networkFacial palsyFacial paralysisSynkinesis

Identifiers

PMID40634426
PMCPMC12241590

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.