Evidence map›Paper›PMID 40634301›Full record

ArticleCell death & disease2025

Estrogen rescues muscle regeneration impaired by DUX4 in a humanized xenograft mouse model.

Silvia Maiullari, Giada Mele, Patrizia Calandra, Giorgia di Blasio, Sonia Valentini, Alessio Torcinaro, Isabella Manni, Emanuela Teveroni, Fabio Mancino, Luca Proietti and 16 more

Abstract read
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Silvia Maiullari *Institute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.
Giada Mele *Institute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.ORCID http://orcid.org/0000-0002-3417-213X
Patrizia CalandraInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.
Giorgia di BlasioInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.
Sonia ValentiniInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.
Alessio TorcinaroInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.ORCID http://orcid.org/0000-0002-9436-8783
Isabella ManniIRCCS National Cancer Institute Regina Elena, Roma, Italy.
Emanuela TeveroniInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.
Fabio MancinoDivision of Orthopaedic and Traumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.ORCID http://orcid.org/0000-0003-3080-0052
Luca ProiettiOperative Unit Spinal Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, UCSC, Roma, Italy.
Fabio MaiullariNational Institute of Molecular Genetics, Milano, Italy.
Maria PesaventoInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.
Ludovica GiorginiInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.
Sabrina PuttiInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.
Roberto RizziNational Institute of Molecular Genetics, Milano, Italy.
Sara BortolaniComplex Operational Unit of Neurology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
Ferdinando ScavizziInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.
Marcello RaspaInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.
Enzo RicciDepartment of Neuroscience, Catholic University of Rome, Roma, Italy.
Giulia PiaggioIRCCS National Cancer Institute Regina Elena, Roma, Italy.ORCID http://orcid.org/0000-0003-2114-1892
Cesare GargioliDepartment of Biology, Rome University Tor Vergata, Roma, Italy.ORCID http://orcid.org/0000-0003-1742-3969
Alfredo PontecorviDepartment of Medicine and Translational Surgery, Catholic University of Roma, Roma, Italy.
Siro LuvisettoInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.ORCID http://orcid.org/0000-0003-1399-2152
Massimiliano MazzoneLaboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, Leuven, Belgium.
Giancarlo DeiddaInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy.
Fabiola MorettiInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Monterotondo, Italy. fabiola.moretti@cnr.it.ORCID http://orcid.org/0000-0002-2691-1254

Funding

AFM-Téléthon (French Muscular Dystrophy Association) 23117
6 · The paper itself

Abstract

Facioscapulohumeral dystrophy (FSHD) is an autosomal dominant muscular dystrophy and one of the most frequent hereditary myopathies. The pathology shows a wide range of clinical signs, with modifying factors contributing to this variability, especially in patients with mild disease. Among these factors, the beneficial activity of estrogen hormones is controversial. We investigated the effect of 17β-estradiol (E

Indexed as

EstradiolEstrogensHomeodomain ProteinsMuscle, SkeletalMuscular Dystrophy, FacioscapulohumeralRegenerationAnimalsDisease Models, AnimalFemaleHeterograftsHumansMesenchymal Stem CellsMiceMyoblastsDUX4L1 protein, humanEstradiolEstrogensHomeodomain Proteins

Identifiers

PMID40634301
PMCPMC12241518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.