Evidence map›Paper›PMID 40634287›Full record

ArticleNature communications2025

Striatal dopamine can enhance both fast working memory, and slow reinforcement learning, while reducing implicit effort cost sensitivity.

Andrew Westbrook, Ruben van den Bosch, Lieke Hofmans, Danae Papadopetraki, Jessica I Määttä, Anne G E Collins, Michael J Frank, Roshan Cools

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrew WestbrookDepartment of Psychiatry, Center for Advanced Human Brain Imaging Research, Rutgers University, Piscataway, NJ, USA. andrew.westbrook@rutgers.edu.ORCID http://orcid.org/0000-0002-7956-2609
Ruben van den BoschDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
Lieke HofmansDepartment of Psychology, University of Amsterdam, Amsterdam, the Netherlands.
Danae PapadopetrakiDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
Jessica I MäättäDepartment of Psychology, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1130-0557
Anne G E CollinsDepartment of Psychology & Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-3751-3662
Michael J Frank *Cognitive, Linguistics, & Psychological Sciences Department, Brown University, Providence, RI, USA.ORCID http://orcid.org/0000-0001-8451-0523
Roshan Cools *Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0001-8994-5534

Funding

The neural network of OCD, linking NHP and human studiesP50MH106435 · NIMH · UNIVERSITY OF ROCHESTER · PI STEVEN A RASMUSSEN · 2015 to 2026
$28.9M
Project 4_Bruchas : Circuit-level Approaches for Dissecting Approach/Avoidance Behaviors Mediated by Nociceptin Systems in MiceP50MH119467 · NIMH · MCLEAN HOSPITAL · PI PIZZAGALLI, DIEGO A · 2020 to 2024
$15.9M
Cognitive Neurocomputational Task Reliability and Clinical Applications ConsortiumR01MH084840 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, Cameron S. Carter · 2008 to 2026
$8.5M
Subjective Cognitive Effort Indexes Sub-Criticality in the BrainR00MH125021 · NIMH · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI WESTBROOK, JOHN ANDREW · 2023 to 2025
$739k
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) CHEMCONTROL#101054532National Science Foundation (NSF) 2336466Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) #453-14-015NIMH NIH HHS P50 MH106435NIMH NIH HHS P50 MH119467NIMH NIH HHS R00 MH125021NIMH NIH HHS R01 MH084840U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) P50MH119467U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R00MH125021U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH084840
6 · The paper itself

Abstract

Associations can be learned incrementally, via reinforcement learning (RL), or stored instantly in working memory (WM). While WM is fast, it is also capacity-limited and effortful. Striatal dopamine may promote WM, by facilitating WM updating and effort exertion and also RL, by boosting plasticity. Yet, prior studies have failed to distinguish between the effects of dopamine manipulations on RL versus WM. N = 100 participants completed a paradigm isolating these systems in a double-blind study measuring dopamine synthesis with [

Indexed as

Corpus StriatumDopamineLearningMemory, Short-TermReinforcement, PsychologyAdolescentAdultBenzamidesDopamine D2 Receptor AntagonistsDouble-Blind MethodFemaleHumansMaleMethylphenidatePositron-Emission TomographyPyrrolidinesBenzamidesDopamineDopamine D2 Receptor AntagonistsMethylphenidateN-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamidePyrrolidinesReceptors, Dopamine D2Sulpiride

Identifiers

PMID40634287
PMCPMC12241355

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.