Evidence map›Paper›PMID 40634186›Full record

ArticleBritish journal of anaesthesia2025

Bone cement implantation syndrome: a scoping review.

Karen E Brokke, Manon Graman, Sjoerd Servaas, Inger N Sierevelt, Monique A H Steegers, Peter A Nolte

Abstract readScoping Review
In one paragraph

Article in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. [Frontier research on smart delivery biomaterials in the field of oral tissue engineering].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karen E BrokkeDepartment of Orthopaedic Surgery, Spaarne Gasthuis Academy, Hoofddorp, The Netherlands; Department of Anaesthesiology, Amsterdam Movement Sciences, Amsterdam University Medical Centers, Amsterdam, The Netherlands. Electronic address: kbrokke@spaarnegasthuis.nl.
Manon GramanDepartment of Anaesthesiology, University Medical Centers Utrecht, Utrecht, The Netherlands.
Sjoerd ServaasDepartment of Anaesthesiology, Spaarne Gasthuis Academy, Hoofddorp, The Netherlands.
Inger N SiereveltDepartment of Orthopaedic Surgery, Spaarne Gasthuis Academy, Hoofddorp, The Netherlands; Department of Orthopaedic Surgery and Sports Medicine, Amsterdam Movement Sciences, Amsterdam University Medical Centers, Amsterdam, The Netherlands; Department of Orthopaedic Surgery, Xpert Clinics, Amsterdam, The Netherlands.
Monique A H SteegersDepartment of Anaesthesiology, Amsterdam Movement Sciences, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Peter A NolteDepartment of Orthopaedic Surgery, Spaarne Gasthuis Academy, Hoofddorp, The Netherlands; Department of Oral Cell Biology, Academic Centre for Dentistry, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBone cement implantation syndrome comprises the occurrence of hypoxaemia, hypotension, unexpected loss of consciousness, or cardiac arrest occurring around the time of cementation, prosthesis insertion, or reduction of the joint in arthroplasty. As the yearly number of arthroplasties will increase, the number of complications including bone cement implantation syndrome is also expected to increase. Therefore, a good understanding of this syndrome is important. This scoping review aims to provide a comprehensive overview of the current knowledge of bone cement implantation syndrome.

methodsThis scoping review was conducted based on the PRISMA-ScR Checklist. A literature search was done in PubMed, Cochrane, and Embase. A total of 85 studies were included in the study.

resultsThe incidence of bone cement implantation syndrome during cemented hip or knee arthroplasty varied from 15.4% to 46.7% and 27.5% to 70.7%, respectively. The incidence in shoulder arthroplasty was 16.2%. In uncemented hip arthroplasty, the incidence ranged from 0.0% to 21.8%. Risk factors identified for bone cement implantation syndrome included advanced age, ASA physical status 3 or 4, and primary lung cancer or lung metastasis.

conclusionsBone cement implantation syndrome is a potentially severe complication that can occur during both cemented and uncemented arthroplasty. Moreover, the occurrence of bone cement implantation syndrome is not dependent on the use of cement. However, the severity does seem to have an association with the fixation method.

Indexed as

Bone CementsPostoperative ComplicationsArthroplasty, Replacement, HipHumansRisk FactorsSyndromeBone Cementsbone cement implantation syndromecementationcemented arthroplastydesaturationhypotensionhypoxiauncemented arthroplasty

Identifiers

PMID40634186
PMCPMC12674061

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.