ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
Activation of Dopamine D1 Receptors at the Axon Initial Segment-Like Process of Retinal AII Amacrine Cells Modulates Action Potential Firing.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Validation of eye occluding device developed from bottle caps for dopamine studies in rabbits: A pilot study.Open veterinary journal · 2026Article
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5 authors.
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Abstract
Dopamine is an important neuromodulator found throughout the central nervous system that can influence neural circuits involved in sensory, motor, and cognitive functions. In the retina, dopamine is released by specific amacrine cells and plays a role in reconfiguring circuits for photopic vision. This adaptation takes place both in photoreceptors and at postreceptoral sites. The AII amacrine cell, which plays a crucial role for transmission of both scotopic and photopic visual signals, has been considered an important target of dopaminergic modulation, expressed as a change in the strength of electrical coupling mediated by gap junctions between the AIIs. It has been difficult, however, to find clear evidence for expression of dopamine receptors by AII amacrines. Here, we combined injection of fluorescent dye in AIIs with immunolabeling of type 1 dopamine receptors (D1Rs) and made the surprising observation that D1Rs, along with KCNQ2, an M-type K
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