Evidence map›Paper›PMID 40634123›Full record

ArticleeNeuro2025

Novel Roles of the GPI-Anchor Cleaving Enzyme, GDE2, in Hippocampal Synaptic Morphology and Function.

Daniel Daudelin, Damani Sama-Borbon, Nan Zhang, Shanthini Sockanathan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel DaudelinThe Solomon Snyder Department of Neuroscience, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205.
Damani Sama-BorbonThe Solomon Snyder Department of Neuroscience, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205.
Nan ZhangThe Solomon Snyder Department of Neuroscience, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205.
Shanthini SockanathanThe Solomon Snyder Department of Neuroscience, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205 ssockan1@jhmi.edu.ORCID https://orcid.org/0000-0003-4147-4782

Funding

Training Program in NeuroscienceT32NS091018 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JAMES J KNIERIM, Daniel Hans O'Connor · 2015 to 2026
$4.1M
Mechanisms of amyloid precursor protein processing: novel regulation of α-secretase activityRF1AG062671 · NIA · JOHNS HOPKINS UNIVERSITY · PI SOCKANATHAN, SHANTHINI · 2019 to 2019
$2.7M
Investigating pathways of hippocampal synaptic funtion: potential implications for Alzheimer's diseaseF31AG079539 · NIA · JOHNS HOPKINS UNIVERSITY · PI DAUDELIN, DANIEL · 2023 to 2025
$146k
NIA NIH HHS F31 AG079539NIA NIH HHS RF1 AG062671NINDS NIH HHS T32 NS091018
6 · The paper itself

Abstract

Hippocampal synaptic activity is tightly regulated to ensure appropriate synaptic function and plasticity, which are important for critical cognitive processes such as learning and memory. Altered hippocampal synaptic function can lead to cognitive and behavioral deficits observed in neurodegenerative diseases such as Alzheimer's disease (AD), necessitating a deeper fundamental understanding of hippocampal synaptic control mechanisms. Glycerophosphodiester phosphodiesterase 2 (GDE2 or GDPD5) is a surface transmembrane enzyme that cleaves the glycosylphosphatidylinositol anchor that tethers some proteins to the membrane. Mice lacking GDE2 (

Indexed as

CA1 Region, HippocampalHippocampusPhosphoric Diester HydrolasesSynapsesAnimalsExcitatory Postsynaptic PotentialsMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, N-Methyl-D-Aspartateglycerophosphodiester phosphodiesterasePhosphoric Diester HydrolasesReceptors, N-Methyl-D-AspartateGDE2hippocampusmorphologyNMDAR-LTDPI3K signaling

Identifiers

PMID40634123
PMCPMC12320762

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.