ArticleInternal medicine (Tokyo, Japan)2026
Ventricular Tachycardia and Takotsubo-like Syndrome in a Patient Undergoing Afatinib Treatment for Advanced Lung Adenocarcinoma.
Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Reply to the Letter by Kataoka et al.: Evidence Supporting a Ventricular Origin in Afatinib-associated Arrhythmia.Internal medicine (Tokyo, Japan) · 2026Article
- A Detailed Assessment of an Electrocardiogram During an Arrhythmic Attack in a Patient Receiving Afatinib.Internal medicine (Tokyo, Japan) · 2026Article
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8 authors.
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Abstract
Afatinib is a second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor approved for the treatment of non-small-cell lung cancer. We herein report a 61-year-old woman who developed dyspnea and ventricular tachycardia (VT) after afatinib treatment for lung adenocarcinoma. Following restoration of sinus rhythm with continuous amiodarone infusion, echocardiography and cardiac computed tomography revealed Takotsubo-like left ventricular wall motion abnormalities. Unfortunately, the patient's cardiac function did not improve, and she developed circulatory failure, which resolved on day 3 of hospitalization. Takotsubo-like cardiac dysfunction and VT should be recognized as potential side effects of afatinib.
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