Predicting Cerebral Aneurysm Rupture: The Role of Computational Fluid Dynamics.

Farshid Goudarzian, Kostiantyn Kondratiuk, Vitaliy L Rayz

Abstract readReview

In one paragraph

Review in Neuroimaging clinics of North America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Achievement and Future Prospectives from Translational Research Targeting Intracranial Aneurysm.Neurologia medico-chirurgica · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Farshid GoudarzianWeldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, IN 47907, USA.

Kostiantyn KondratiukWeldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, IN 47907, USA.

Vitaliy L RayzWeldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, IN 47907, USA; School of Mechanical Engineering, Purdue University, West Lafayette, USA. Electronic address: vrayz@purdue.edu.

Funding

Risk Assessment of Cerebral Aneurysm Growth with 4D flow MRIR01HL115267 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANSARI, SAMEER A, LAWTON, MICHAEL T · 2013 to 2023

$4.2M

NHLBI NIH HHS R01 HL115267

6 · The paper itself

Abstract

Intracranial aneurysms (IAs) are outpouchings of cerebral arteries that may rupture, associated with high morbidity and mortality. While most unruptured IAs remain stable, they are often treated due to the severe consequences of rupture. Current IA rupture risk scores rely on clinical and morphological factors but do not account for blood flow, which may limit their predictive accuracy. Image-based Computational Fluid Dynamics (CFD) can capture local hemodynamics, but studies linking flow factors to IA rupture have yielded conflicting results. This review presents CFD methods for subject-specific IA flow analysis and discusses challenges in translating computational modeling into clinical practice.

Indexed as

Aneurysm, RupturedIntracranial AneurysmCerebrovascular CirculationComputer SimulationHemodynamicsHumansHydrodynamicsHemodynamicsImage-based modelingPatient-specific flow simulations

Identifiers

PMID40634002

DOI10.1016/j.nic.2025.05.002

PMCPMC13588319

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.