ArticleTherapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy2025
Peritoneal Lavage With Low GDP Neutral pH PD Solution Reduces Mortality and Severity in a Lethal Peritonitis Model.
Article in Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Peritoneal Lavage With Low GDP Neutral pH PD Solution Reduces Mortality and Severity in a Lethal Peritonitis Model.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2025Article
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8 authors.
Funding
Abstract
introductionThe efficacy of peritoneal lavage monotherapy using PD solution for severe peritonitis remains unproven.
methodsWe evaluated the effects of 3-times and 6-times lavage using low GDP neutral PD solution on a Methicillin-sensitive Staphylococcus aureus (MSSA) lethal peritonitis model rats without antibiotic use. Changes in effluent viable bacteria numbers dependent on lavage frequency were determined in a further 10 rats.
resultsCompared to the lethal peritonitis model without lavage, both 3-times and 6-times lavage significantly reduced 24-h mortality, effluent FDP and creatinine concentrations. Furthermore, 6-times lavage significantly prevented the rough fur development, intraabdominal adhesion, and pus formation which developed in both the 0-times and 3-times lavage groups. The effluent viable bacterial counts showed significant step-ladder decreases with an increasing number of the lavages.
conclusionWe demonstrated for the first time that lavage monotherapy using PD solution reduces mortality and severity in a lethal peritonitis model by rapidly eliminating bacteria without antibiotic use.
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