ArticleBiological psychiatry2026
Impact of Inflammation on White Matter Integrity and Functional Connectivity in Chronic Major Depressive Disorder.
Article in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Effects of Dopaminergic Therapy with Levodopa (L-DOPA) on Fear and Anxiety-Related Circuits and Symptoms in Patients with Depression and Higher Inflammation.Brain, behavior, and immunity · 2026Trial
- Characterizing Illness Course to Understand the Role of Inflammation on Brain Structure and Function in Individuals With Depression.Biological psychiatry · 2026Article
- Aberrant topology of the default mode network is associated with phosphatidylcholine and triglyceride levels in major depressive disorder.World journal of psychiatry · 2026Article
- Linking inflammatory and structural neuroimaging biomarkers in treatment-resistant depression: Current evidence and emerging hypotheses.Neuroscience applied · 2026Review
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Authors and funding
9 authors.
Funding
Abstract
backgroundInflammation is increasingly recognized as a pathophysiologic component of major depressive disorder (MDD). Concurrently, depressive episode chronicity has emerged as a significant predictor of adverse long-term outcomes.
methodsUtilizing data from the PReDICT (Predictors of Remission in Depression to Individual and Combined Treatments) study, our analysis included 201 participants who completed C-reactive protein (CRP) sampling and diffusion-weighted imaging scans; of these, 120 participants had usable functional magnetic resonance imaging scans. Chronicity was classified as the presence of a current depressive episode ≥2 years in duration. We examined the impact of inflammation on brain structure and function in MDD, focusing specifically on differences related to chronicity, as well as the interactions between inflammation and functional and structural alterations.
resultsNo significant correlations were observed between CRP concentrations and either functional connectivity (FC) or fractional anisotropy (FA). In patients with chronic, but not nonchronic, MDD, higher CRP concentrations were associated with lower FA in several neural pathways, including the cingulum and frontal aslant tracts. Significant CRP × MDD chronicity interactions were also observed for FC within the default mode network (DMN) and the salience network (SN). Moreover, mediation analyses demonstrated both direct and FA-mediated effects of CRP on FC within the SN in patients with chronic MDD.
conclusionsInteractions based on depressive episode chronicity between CRP and neurobiological function, potentially mediated by reductions in white matter integrity, suggest a potential pathophysiological process in some patients with chronic MDD. The differences in FC suggest specific compensatory adjustments within the DMN and SN among patients with chronic MDD.
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