Evidence map›Paper›PMID 40633882›Full record

ArticleBiological psychiatry2026

Exploring the Pathways Between Early Auditory Processing, Processing Speed, Social Cognition, and Negative Symptoms on Social Functioning in Individuals at Clinical High Risk for Psychosis: A Structural Equation Modeling Approach.

Ricardo E Carrión, Majnu John, Sarah Dorvil, Andrea Auther, Danielle McLaughlin, Mitchell Arnovitz, Peter Bachman, Aysenil Belger, Erica Duncan, Holly Hamilton and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Ricardo E CarriónNorthwell, New Hyde Park, New York; Institute of Behavioral Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York; Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York. Electronic address: rcarrion@northwell.edu.
Majnu JohnNorthwell Health, Glen Oaks, New York.
Sarah DorvilDepartment of Psychology, Queens College, Queens, New York.
Andrea AutherDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York; Northwell Health, Glen Oaks, New York.
Danielle McLaughlinNorthwell Health, Glen Oaks, New York.
Mitchell ArnovitzNorthwell Health, Glen Oaks, New York.
Peter BachmanDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Aysenil BelgerDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Erica DuncanAtlanta Veterans Affairs Health Care System, Decatur, Georgia; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
Holly HamiltonDepartment of Psychiatry, University of California, San Francisco, San Francisco, California; Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota; Department of Psychology, University of Minnesota, Minneapolis, Minnesota.
Jason JohannesenDepartment of Psychiatry, Yale University, School of Medicine, New Haven, Connecticut.
Benson KuAtlanta Veterans Affairs Health Care System, Decatur, Georgia.
Gregory LightDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Margaret NiznikiewiczDepartment of Psychiatry, Harvard University, Cambridge, Massachusetts (MN).
Brian J RoachSan Francisco Veterans Affairs Health Care System, San Francisco, California.
Jean AddingtonDepartment of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
Carrie E BeardenDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California; Department of Psychology, University of California, Los Angeles, Los Angeles, California.
Kristin S CadenheadDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Tyrone D CannonDepartment of Psychiatry, Yale University, School of Medicine, New Haven, Connecticut; Department of Psychology, Yale University, School of Medicine, New Haven, Connecticut.
Matcheri KeshavanDepartment of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, Massachusetts.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
William S StoneDepartment of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, Massachusetts.
Ming TsuangDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Elaine F WalkerAtlanta Veterans Affairs Health Care System, Decatur, Georgia; Department of Psychology, Emory University, Atlanta, Georgia.
Scott W WoodsDepartment of Psychiatry, Yale University, School of Medicine, New Haven, Connecticut; Department of Psychology, Yale University, School of Medicine, New Haven, Connecticut.
Daniel H MathalonDepartment of Psychiatry, University of California, San Francisco, San Francisco, California; San Francisco Veterans Affairs Health Care System, San Francisco, California.
Barbara A CornblattInstitute of Behavioral Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York; Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York; Northwell Health, Glen Oaks, New York; Department of Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.

Funding

Impact of Neighborhood Characteristics on Conversion to Psychosis among Youth at Clinical High Risk for PsychosisK23MH129684 · NIMH · EMORY UNIVERSITY · PI Benson Ku · 2022 to 2026
$970k
NIMH NIH HHS K23 MH129684
6 · The paper itself

Abstract

backgroundSocial functioning difficulties in adolescents and young adults at clinical high risk for psychosis (CHR-P) are among the strongest risk factors for psychosis onset. Recent research in patients with schizophrenia has demonstrated complex relationships between early auditory processing deficits as measured by the mismatch negativity (MMN) response of the auditory event-related potential, neurocognition, social cognition, negative symptoms, and social functioning. However, the interrelationships of these variables and associations with social functioning impairments prior to the onset of the illness are unclear. The present study used a structural equation modeling (SEM) approach to integrate these factors to determine the specific determinants that lead to poor social functioning in CHR-P youth.

methodsA total of 518 CHR-P individuals from the NAPLS2 (North American Prodrome Longitudinal Study) were used to evaluate SEMs with pathways starting from MMN to social functioning. The intervening variables included processing speed, social cognition, and negative symptoms.

resultsA final trimmed model revealed that early auditory processing (MMN) had a direct effect on processing speed, and both processing speed and negative symptoms had direct effects on social functioning. The direct effect from social cognition to social functioning was not significant.

conclusionsOur findings suggest that neurophysiological deficits are associated with social functioning by way of processing speed impairments, which fully accounted for the relationship in CHR-P youths prior to psychosis onset. These results may have implications for early intervention strategies that target early information-processing deficits with the aim of improving social trajectories and limiting psychosis onset in young CHR-P individuals.

Indexed as

Auditory PerceptionEvoked Potentials, AuditoryPsychotic DisordersSocial CognitionAdolescentAdultElectroencephalographyFemaleHumansLatent Class AnalysisLongitudinal StudiesMaleProcessing SpeedProdromal SymptomsYoung AdultClinical high risk for developing psychosisEvent-related potentialsMismatch negativityProcessing speedSocial cognitionStructural equation modeling (SEM)

Identifiers

PMID40633882
PMCPMC13047931

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.