ArticlePsychiatry investigation2025
Prospective Associations of Serum Tumor Necrosis Factor-Alpha and Employment on Suicidal Behaviors Over 1 Year in Depressive Patients Receiving Psychopharmacotherapy.
Article in Psychiatry investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Employment Status Shapes the Link between Serum Tumor Necrosis Factor and Suicidal Ideation in Patients with Acute Coronary Syndrome: Evidence from an Independent Clinical Cohort.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
objectiveThis study explored both the individual and combined effects of serum tumor necrosis factor-alpha (sTNF-α) levels and employment status on suicidal behavior (SB) in patients with depressive disorders undergoing pharmacologic treatment.
methodsBaseline measurements of sTNF-α levels were taken, and employment status was determined. Over a 1-year period of stepwise pharmacotherapy, SB was monitored and categorized into increased suicidal severity and fatal/non-fatal suicide attempts. Logistic regression models adjusted for relevant covariates were used to analyze the individual and interactive associations between sTNF-α levels, employment status, and these two forms of SB.
resultsUnemployment was significantly associated with both forms of SB, whereas sTNF-α levels alone did not show a significant correlation. However, lower sTNF-α levels combined with employment were associated with the lowest incidence rates of both SB categories, demonstrating significant interactive effects after adjustment.
conclusionThe study demonstrates that the prospective associations of sTNF-α levels for SB is enhanced when combined with employment status in patients receiving pharmacological treatment for depressive disorders. These findings suggest that integrating biological markers with socio-economic factors can improve the assessment and management of suicide risk.
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