Evidence map›Paper›PMID 40633520›Full record

ArticleJournal of psychosomatic research2025

Beyond total depressive symptoms: Differential associations between depressive domains, HIV status and disease characteristics.

Maximo Prescott, Crystal Wang, Miya Gentry, Donald Franklin, Murray B Stein, Joseph Hampton Atkinson, Ronald Ellis, Robert K Heaton, Jessica Montoya, David Moore and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychosomatic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Advances in Treatment of Psychiatric Disorders in Patients with HIV.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maximo PrescottHIV Neurobehavioral Research Program, University of California San Diego, San Diego, CA, USA; San Diego State University/University of California San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA. Electronic address: mrprescott@health.ucsd.edu.
Crystal WangHIV Neurobehavioral Research Program, University of California San Diego, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, USA.
Miya GentrySan Diego State University/University of California San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA; Sam and Rose Stein Institute for Research on Aging/Center for Healthy Aging, University of California, San Diego, La Jolla, CA, USA.
Donald FranklinHIV Neurobehavioral Research Program, University of California San Diego, San Diego, CA, USA.
Murray B SteinHIV Neurobehavioral Research Program, University of California San Diego, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, USA.
Joseph Hampton AtkinsonHIV Neurobehavioral Research Program, University of California San Diego, San Diego, CA, USA.
Ronald EllisHIV Neurobehavioral Research Program, University of California San Diego, San Diego, CA, USA; Department of Neurosciences, University of California San Diego, La Jolla, USA.
Robert K HeatonHIV Neurobehavioral Research Program, University of California San Diego, San Diego, CA, USA.
Jessica MontoyaHIV Neurobehavioral Research Program, University of California San Diego, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, USA.
David MooreHIV Neurobehavioral Research Program, University of California San Diego, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, USA.
Jennifer IudicelloHIV Neurobehavioral Research Program, University of California San Diego, San Diego, CA, USA.

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jessica Lynette Montoya · 2001 to 2026
$50.4M
California NeuroAIDS Tissue NetworkU24MH100928 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACHIM, CRISTIAN L, MOORE, DAVID J · 2013 to 2023
$13.9M
Age related determinants of HAND: A 12 year follow-up of CHARTER participantsR01MH107345 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEATON, ROBERT KERNACHAN, LETENDRE, SCOTT L · 2015 to 2021
$7.9M
Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)T32DA031098 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello, DAVID J MOORE · 2011 to 2026
$4.6M
Identification of Biomarkers of CNS injury and resilience related to HIV-1 and MethamphetamineR01DA047879 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IUDICELLO, JENNIFER E, LETENDRE, SCOTT L · 2018 to 2022
$3.7M
An integrated incentive-based treatment to optimize HIV treatment engagement among persons who use methamphetamineK23DA051324 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MONTOYA, JESSICA LYNETTE · 2021 to 2025
$1.0M
NIDA NIH HHS K23 DA051324NIDA NIH HHS R01 DA047879NIDA NIH HHS T32 DA031098NIMH NIH HHS HHSN271201000030CNIMH NIH HHS HHSN271201000036CNIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH107345NIMH NIH HHS U24 MH100928
6 · The paper itself

Abstract

backgroundPeople with HIV (PWH) are at two times greater risk for major depressive disorder (MDD) than people without HIV (PWoH), which manifests in symptoms across cognitive, somatic, affective, apathy, and anhedonia domains that may differentially impact clinical outcomes. However, few studies have examined whether HIV and its characteristics relate to depressive symptom domains.

methodsThis secondary, cross-sectional analysis included 3456 participants enrolled in studies at the UCSD HIV Neurobehavioral Research Program and CHARTER sites between 2000 and 2023 (79 % PWH, 78 % male, Age: M = 47.8). Depressive symptom domains were assessed with the Beck Depression Inventory (BDI-II). Multivariable linear regression models evaluated associations between HIV, HIV disease characteristics, and depressive symptom domains while controlling for covariates.

resultsHIV diagnosis was significantly associated with higher severity across depressive symptom domains (affective: B = 0.51, cognitive: B = 0.44, somatic: B = 1.55, anhedonia: B = 0.52, apathy: B = 0.58, all ps < 0.05) and overall depressive symptoms (BDI-II total: B = 2.51, p < 0.01) while adjusting for covariates. Among PWH, HIV viral suppression was associated with fewer overall depressive symptoms, driven by fewer cognitive and somatic symptoms (ps < 0.01), while higher current CD4

conclusionHIV diagnosis was associated with higher depressive symptoms across all domains. Current HIV disease indicators and duration of HIV disease were associated with select depressive domains to varying degrees, except for the anhedonia domain. These findings highlight the potential importance of examining individual symptom domains as they differentially associate with varying aspects of HIV disease, which may provide insight into specific treatment targets.

Indexed as

DepressionHIV InfectionsMajor Depressive DisorderAdultAnhedoniaApathyCross-Sectional StudiesFemaleHumansMaleMiddle AgedSeverity of Illness IndexDepressionDepressive domainsDepressive symptomsHIVHIV disease characteristics

Identifiers

PMID40633520
PMCPMC12403146

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.