Evidence map›Paper›PMID 40633218›Full record

ArticleThe Plant journal : for cell and molecular biology2025

Triple labeling of metabolites for metabolome analysis (TLEMMA): a stable isotope labeling approach for metabolite identification and network reconstruction.

Yonghui Dong, Liron Feldberg, Yi Wang, Uwe Heinig, Ilana Rogachev, Asaph Aharoni

Abstract read
In one paragraph

Article in The Plant journal : for cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yonghui Dong *Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-0534-3868
Liron Feldberg *Department of Analytical Chemistry, Israel Institute for Biological Research, Ness Ziona, Israel.
Yi WangXi'an Manareco New Materials Co., Ltd., Shaanxi, China.
Uwe HeinigDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.
Ilana RogachevDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.
Asaph AharoniDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-6077-1590

Funding

Ministry of Science and Technology, Israel 3-14297
6 · The paper itself

Abstract

Metabolite identification remains a significant challenge in mass spectrometry (MS)-based metabolomics research. To address this issue, we combined a triple-labeled precursor-based isotope tracing approach (TLEMMA) with high-resolution liquid chromatography-MS for metabolite identification and metabolic network construction. As a demonstration, we fed duckweed (Spirodela polyrhiza) with four forms of phenylalanine (Phe) including unlabeled Phe, Phe-

Indexed as

Isotope LabelingMetabolomeMetabolomicsCarbon IsotopesChromatography, LiquidMass SpectrometryMetabolic Networks and PathwaysPhenylalanineCarbon IsotopesPhenylalaninemetabolite identificationplant metabolomicsstable isotope labelingtechnical advance

Identifiers

PMID40633218
PMCPMC12240604

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.