ArticleJournal of chemical information and modeling2025
Impact of Genetic Variants Associated with Neurodevelopmental Disorders on the WAVE Regulatory Complex.
Article in Journal of chemical information and modeling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Disease-Associated Mutations Impact DNA Methyltransferase 1 Function through Dynamic Allosteric Effects and Solvent Exposure.Journal of chemical theory and computation · 2026Article
- Disulfidptosis: A Metabolic Cell Death Mechanism with Therapeutic Potential in Cancer.Oncology research · 2026Review
- Common characteristics of variants linked to autism spectrum disorder in the WAVE regulatory complex.Frontiers in computational neuroscience · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The WAVE regulatory complex (WRC) is a heteropentamer necessary for the regulation of actin cytoskeleton. Genetic variants in components of the WRC have been associated with increased risk for neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD). Some of the missense variants associated with NDDs have been reported to cause aberrant detachment of the WRC domain active C-terminal region (ACR). Using molecular dynamics simulations, we show that these variants cause a similar increase in disorder in a specific helix of ACR as well as a decrease in ACR/WRC interactions, irrespective of their position and chemical nature. These might assist ACR detachment. We further demonstrate their impact on the large-scale motions of the complex. Taken together, these results do suggest that different modifications associated with the NDD-associated variants converge on similar changes to the structural dynamics of the WRC.
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Registered trials
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