Evidence map›Paper›PMID 40633067›Full record

ArticleDiabetes2025

Type 1 Diabetes Autoantibodies in Acute, Recurrent Acute, and Chronic Pancreatitis.

Clive H Wasserfall, Chris E Forsmark, Shuang Li, Liang Li, Phil A Hart, Mark O Goodarzi, Yogish C Kudva, Melena D Bellin, Dhiraj Yadav, Darwin L Conwell and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Clive H WasserfallDepartment of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL.ORCID 0000-0002-3522-8932
Chris E ForsmarkDivision of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL.
Shuang LiDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Liang LiDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Phil A HartDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH.
Mark O GoodarziDivision of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA.
Yogish C KudvaDivision of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN.
Melena D BellinDivision of Pediatric Endocrinology, University of Minnesota, Minneapolis, MN.
Dhiraj YadavDivision of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh, Pittsburgh, PA.
Darwin L ConwellDepartment of Medicine, University of Kentucky, Lexington, KY.
Jose SerranoDivision of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
Dana K AndersenDivision of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
William FisherDepartment of Surgery, Baylor College of Medicine, Houston, TX.
Anna CasuAdventHealth Translational Research Institute, Orlando, FL.
Ken CusiDivision of Endocrinology, Diabetes, and Metabolism, University of Florida, Gainesville, FL.
Steven J HughesDepartment of Surgery, University of Florida, Gainesville, FL.
Evan FogelDivision of Gastroenterology and Hepatology, University of Indiana, Bloomington, IN.
Walter ParkDivision of Gastroenterology and Hepatology, Stanford Medicine, Stanford, CA.
Stephen K Van Den EedenDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA.
Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Project 3P01AI042288 · NIAID · UNIVERSITY OF FLORIDA · PI Todd Michael Brusko · 1997 to 2026
$32.9M
Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer: Coordinating and Data Management Center (CSCPDPC-CDMC)U01DK108328 · NIDDK · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Liang Li, Suyu Liu · 2015 to 2026
$32.8M
Indiana University (IU) Clinical Center for Chronic Pancreatitis Clinical Research NetworkU01DK108323 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Jeffrey James Easler, Evan L Fogel · 2015 to 2026
$6.5M
UPMC Clinical Center for the Study of Chronic Pancreatitis and DiabetesU01DK108306 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Frederico G. S. Toledo, Dhiraj Yadav · 2015 to 2026
$6.4M
The Stanford Clinical Center for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic CancerU01DK108300 · NIDDK · STANFORD UNIVERSITY · PI Sohail Z Husain, Walter Gwang-Up Park · 2015 to 2026
$6.3M
Pathophysiology, Epidemiology, and Prevention of Pancreatogenic Diabetes - Administrative SupplementU01DK108314 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Mark Goodarzi, Stephen J. Pandol · 2015 to 2026
$6.1M
The Exocrine and Endocrine Pancreas in Type 2 Diabetes, Pancreatitis and Cancer (Admin Supplement)U01DK108288 · NIDDK · MAYO CLINIC ROCHESTER · PI Santhi Swaroop Vege · 2015 to 2026
$5.9M
The Ohio State University Pancreatic Disorders Network (OSU-PDN)U01DK108327 · NIDDK · OHIO STATE UNIVERSITY · PI CONWELL, DARWIN LEWIS, HART, PHILIP A. · 2015 to 2024
$5.5M
DYSBIOTIC MICROBIOME IN PANCREATITIS, DIABETES, AND PANCREATIC CANCERU01DK108326 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI FISHER, WILLIAM E · 2015 to 2024
$5.2M
U-01 CONSORTIUM FOR THE STUDY OF CHRONIC PANCREATITIS,DIABETES AND PANCREATIC CANCER CLINICAL CENTERSU01DK108320 · NIDDK · UNIVERSITY OF FLORIDA · PI CUSI, KENNETH, FORSMARK, CHRISTOPHER E · 2015 to 2024
$4.6M
Chronic Pancreatitis, Diabetes and Pancreatic Cancer: A Prospective ApproachU01DK108332 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI VAN DEN EEDEN, STEPHEN K. · 2015 to 2019
$1.9M
National Institute of Allergy and Infectious Diseases P01AI042288NCI NIH HHSNIAID NIH HHS P01 AI042288NIDDK NIH HHS P30 DK063491NIDDK NIH HHS U01 DK108288NIDDK NIH HHS U01DK108288NIDDK NIH HHS U01 DK108300NIDDK NIH HHS U01DK108300NIDDK NIH HHS U01 DK108306NIDDK NIH HHS U01DK108306NIDDK NIH HHS U01 DK108314NIDDK NIH HHS U01DK108314NIDDK NIH HHS U01 DK108320NIDDK NIH HHS U01DK108320NIDDK NIH HHS U01 DK108323NIDDK NIH HHS U01DK108323NIDDK NIH HHS U01 DK108326NIDDK NIH HHS U01DK108326NIDDK NIH HHS U01 DK108327NIDDK NIH HHS U01DK108327NIDDK NIH HHS U01 DK108328NIDDK NIH HHS U01DK108328NIDDK NIH HHS U01 DK108332NIDDK NIH HHS U01DK108332NIDDK NIH HHS U01 DK144496NIH HHS P30DK063491
6 · The paper itself

Abstract

article highlightsType 1 diabetes-associated autoimmune mechanisms have not been thoroughly examined in pancreatitis-associated diabetes. We assessed the prevalence of four islet autoantibodies in serum from a large prospective cohort of patients with acute, recurrent acute, or chronic pancreatitis. Diabetes was present in 11 (12%) of 94 participants with acute pancreatitis, 69 (27%) of 273 with recurrent acute pancreatitis, and 235 (43%) of 560 with chronic pancreatitis. Excluding those with only insulin autoantibody positivity, which is confounded by insulin treatment, islet autoantibodies were identified in 51 (5.5%) of 927 participants, and 30 (3.2%) of 297 were positive for two or more autoantibodies. Our findings suggest pancreatitis may elicit islet autoimmunity in a subset of patients, necessitating prospective longitudinal follow-up.

Indexed as

AutoantibodiesDiabetes Mellitus, Type 1PancreatitisPancreatitis, ChronicAcute DiseaseAdultAutoimmunityFemaleHumansIslets of LangerhansMaleMiddle AgedProspective StudiesRecurrenceYoung AdultAutoantibodies

Identifiers

PMID40633067
PMCPMC12365414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.