Evidence map›Paper›PMID 40632885›Full record

ArticleACS chemical neuroscience2025

Selective Modulation of Trk Receptors by

Shaon Joy, Tianxiong Mi, Rui-Liang Lyu, Thitima Pewklang, Tye Thompson, Arthur Sefiani, Anyanee Kamkaew, Kevin Burgess

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shaon JoyDepartment of Chemistry, Texas A&M University, Box 30012, College Station, Texas 77842-3012, United States.
Tianxiong MiDepartment of Chemistry, Texas A&M University, Box 30012, College Station, Texas 77842-3012, United States.ORCID 0000-0003-4014-4060
Rui-Liang LyuDepartment of Chemistry, Texas A&M University, Box 30012, College Station, Texas 77842-3012, United States.
Thitima PewklangDepartment of Chemistry, Texas A&M University, Box 30012, College Station, Texas 77842-3012, United States.
Tye ThompsonDepartment of Chemistry, Texas A&M University, Box 30012, College Station, Texas 77842-3012, United States.
Arthur SefianiDepartment of Neuroscience and Experimental Therapeutics, Health Science Center, Texas A&M University, Bryan, Texas 77807, United States.
Anyanee KamkaewSchool of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Kevin BurgessDepartment of Chemistry, Texas A&M University, Box 30012, College Station, Texas 77842-3012, United States.ORCID 0000-0001-6597-1842

Funding

Mid-sized GDNF Minics for Neural regenerationR21NS130471 · NINDS · TEXAS A&M UNIVERSITY · PI BURGESS, KEVIN · 2023 to 2024
$537k
NINDS NIH HHS R21 NS130471
6 · The paper itself

Abstract

Neurotrophins (NTs, including NGF, BDNF, NT-4, and NT-3) are extracellular cytokines which modulate the survival and growth of cells expressing tropomyosin receptor kinases (Trks) A-C. Cells which express Trks include many neural tissues. For instance, corneal nerves secrete NTs to counteract epithelium disruption. Potential therapeutic applications of Trk agonism are numerous, but the use of NTs is limited by problems with production, in vivo stability, and side effects of the protein. Only humanized recombinant NGF has been clinically approved: Cenegermin for treatment of neurotrophic keratitis (NK) in the eye. Consequently, low molecular mass Trk agonists are of interest as surrogates for humanized NTs. One low molecular mass TrkA modulator from our lab, a

Indexed as

Peptides, CyclicReceptor, trkAReceptor, trkCAnimalsHumansMiceNerve Growth FactorsReceptor, trkBNerve Growth FactorsPeptides, CyclicReceptor, trkAReceptor, trkBReceptor, trkCagonistcyclo-organopeptidesloop mimicsneurotrophinspotentiatorTrk receptors

Identifiers

PMID40632885
PMCPMC12333011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.