Evidence map›Paper›PMID 40632860›Full record

ArticleScience advances2025

Dual-phoretic wireless device for directionally oriented and carrier-free targeted drug delivery.

Sung-Geun Choi, Seongchan Kim, Joon-Woo Kim, Myung-Kyun Choi, Jieun Han, Dong-Jun Koo, Soo-Hwan Lee, Aejin Kim, Ji-Woo Gu, Ki Hun Kim and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Biointegrated Battery-Based Electroceuticals.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sung-Geun ChoiDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0002-0445-3926
Seongchan KimBiomaterials Research Center, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.ORCID 0000-0002-2104-6599
Joon-Woo KimDepartment of Electronic Convergence Engineering, Kwangwoon University, Seoul 01897, Republic of Korea.
Myung-Kyun ChoiDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea.
Jieun HanDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea.
Dong-Jun KooInstitute of Molecular Biology and Genetics, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0002-0596-1252
Soo-Hwan LeeBiomaterials Research Center, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.ORCID 0009-0001-4764-030X
Aejin KimBiomaterials Research Center, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.ORCID 0009-0001-9581-8053
Ji-Woo GuDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0002-9195-7830
Ki Hun KimDoping Control Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.ORCID 0000-0002-0962-1837
Ju-Yong LeeDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0002-9267-1594
Jae-Young BaeDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0009-0005-7049-5138
Sung-Yon KimInstitute of Molecular Biology and Genetics, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0003-0791-7308
Jeonghyun KimDepartment of Electronic Convergence Engineering, Kwangwoon University, Seoul 01897, Republic of Korea.ORCID 0000-0003-3090-1435
Hyojin LeeBiomaterials Research Center, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.ORCID 0000-0001-6367-9485
Seung-Kyun KangDepartment of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0001-9779-8976

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug localization, release control, and penetration into solid tissues through biological tight junctions are crucial for the treatment of localized diseases with biological barriers by maximizing therapeutic efficacy of the drug and minimizing damage to normal organs. Here, we introduce a dual-phoretic wireless drug delivery system that harnesses the physical control of ion transportation: electrophoresis for controllable release and iontophoresis for directional penetration. Adjustable, pulsatile, and repeatable drug release under biological conditions is achieved using ion diodes and Zn-based electrochemical cells. Through seamless integration with iontophoretic compartments, a fourfold improvement in delivery efficiency compared to drug diffusion, reaching the core of in vivo tumor, is verified by a 3D tomographic analysis. Fully implantable and wireless operation in a simulated 2-week therapeutic scenario results in a remarkable 50% tumor reduction from the initial volume while minimizing damage to nearby normal tissue and off-target organs such as the heart, liver, spleen, and kidney.

Indexed as

Drug Delivery SystemsWireless TechnologyAnimalsCell Line, TumorDrug LiberationHumansMice

Identifiers

PMID40632860
PMCPMC12239951

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.