ArticleScience advances2025
Striatal dopamine signals errors in prediction across different informational domains.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Characterization of nucleus accumbens dopamine dynamics during positive and negative operant reinforcement in rats.bioRxiv : the preprint server for biology · 2026Article
- Spatiotemporally Distinct Dopamine Domains in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- KChIP4a is a Biophysical Amplifier of Inhibition in Atypical Dopamine Neurons and Controls Learning from Negative Prediction Errors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A brief history of dopamine prediction errors.Frontiers in computational neuroscience · 2026Review
- Different Effects of Peer Sex on Operant Responding for Social Interaction and Striatal Dopamine Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Dopamine is classically thought to drive learning based on errors in the prediction of rewards and punishments. However, animals also learn to predict cues with no intrinsic value or biological relevance to ongoing behavior, and it is unclear whether such latent learning also relies on dopaminergic prediction errors. Here, we tested this by recording dopamine release in the nucleus accumbens and dorsomedial striatum while rats executed a sensory preconditioning task that incorporated both types of learning. We found that dopamine release in both regions correlated with errors in predicting value-neutral cues during latent learning and with errors in predicting reward during reward-based conditioning. Moreover, dopamine in the nucleus accumbens reflected inferred value in the probe test, supported by orbitofrontal cortex activity. Our findings show that dopamine signals prediction errors about both valued and neutral stimuli, consistent with its operation as a general teaching signal that supports learning across different informational domains.
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Registered trials
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