Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Fang ChenKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan Med-X Center for Materials, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.ORCID 0009-0000-0410-7444
Zhidi HeKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan Med-X Center for Materials, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.ORCID 0009-0004-3975-6806
Rong GuoDepartment of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, P.R. China.ORCID 0009-0009-2553-4539
Min LiKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan Med-X Center for Materials, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.ORCID 0000-0003-4682-7612
Jiaxin LiKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan Med-X Center for Materials, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.ORCID 0009-0007-7514-4702
Yashi WangKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan Med-X Center for Materials, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.ORCID 0009-0000-1475-2981
Xuan HeKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan Med-X Center for Materials, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.ORCID 0009-0008-5345-650X
Zhipeng TianKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan Med-X Center for Materials, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.ORCID 0009-0003-8851-5534
Xiaoli LingKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan Med-X Center for Materials, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.ORCID 0009-0009-9955-1219
Lin XiongKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan Med-X Center for Materials, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.ORCID 0009-0001-1216-637X
Wenjing BaiKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan Med-X Center for Materials, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.ORCID 0009-0009-9613-3484
Man LiKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan Med-X Center for Materials, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.ORCID 0000-0002-5710-5175
Qin HeKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan Med-X Center for Materials, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.ORCID 0009-0009-1126-6940
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Metastasis represents a crucial cancer progression and is promoted by cancer-associated fibroblasts (CAFs). Modulating CAFs in distant metastasis is challenging due to their diverse phenotypes and the lack of effective delivery strategies. Inspired by the tropism of tumor extracellular vesicles (Evs) expressing specific integrins toward fibroblasts, we developed a labeling strategy for both tumors and tumor-derived Evs. Our modified nanoliposomes, by hitchhiking on these labeled Evs, concentrated in CAFs at distant metastatic sites while simultaneously targeting the labeled tumor. This Ev-hitchhiking strategy, in combination with the loaded drugs ATRA and lenvatinib, efficiently regulated the myogenic and inflammatory characteristics of CAFs, remodeled the metastatic microenvironment, and suppressed tumor growth and metastasis. The labeling and Ev-hitchhiking approach holds promise for enhancing tumor elimination and modulating CAFs or other Ev-activated cells in distant metastasis, offering a potential breakthrough in cancer therapy.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Extracellular vesicle-hitchhiking nanoliposomes for cancer-associated fibroblast phenotype modulation impede metastasis progression. · full record | OpenQuestion