ArticleScience advances2025
Developmental Pb exposure increases rate of forgetting on a delayed matching-to-sample task among Mexican children.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Trial
- Iron and Other Metal Ions in Human Health and Disease.MedComm · 2026Review
- Adapting, piloting, and evaluating a pediatric lead screening and risk-reduction intervention in Nairobi: A hybrid implementation-effectiveness trial protocol.medRxiv : the preprint server for health sciences · 2026Article
- Sexual dimorphism in the programming effects of prenatal manganese multi-media biomarker on temporal cognition in school-aged children.Scientific reports · 2026Article
- Lead exposure across early life in Latin America and the Caribbean: prevention strategies and reproductive health considerations.Frontiers in reproductive health · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Lead (Pb) is a potent neurotoxicant, but few studies have evaluated its effect on neurobehavioral measures that can be used in multiple species including humans. We investigated the effect of prenatal and childhood Pb exposure on children's rate of forgetting using a delayed matching-to-sample (DMTS) task among children 6 to 8 years of age. Blood Pb was measured during pregnancy (second and third trimesters) and at 4 to 6 years of age. A nonlinear modified power function was used to predict the forgetting rates on the DMTS task, using separate models for prenatal and childhood Pb. Higher childhood Pb [median (interquartile range), 1.7 (1.3) (μg/dl)] was associated with a faster rate of forgetting (β = -0.05; 95% confidence interval: -0.09, -0.01). Higher maternal intelligence quotient and child's age were significantly associated with a slower rate of forgetting. We validated a unique power function statistical approach for rates of forgetting using Pb exposure.
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