ArticlePLoS neglected tropical diseases2025
Mapping the risk of Zika virus infections in pregnant persons and microcephaly in newborns in relation to socioeconomic indicators in Recife, Pernambuco, Brazil: A spatial analysis (2015 to 2021).
Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Mutations in the NS5 RdRp Domain of Zika and Dengue Viruses: Insights into Molecular Patterns in Inland Midwestern Brazil.Tropical medicine and infectious disease · 2026Article
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Abstract
objectiveUsing spatial analysis techniques, this study investigates the associations between socioeconomic indicators measured at the census tract level and the incidence of Zika virus (ZIKV) infection in pregnant persons and microcephaly in newborns in Recife, Pernambuco, Brazil, from 2015 to 2021.
methodsIn this ecological study, data on cases of ZIKV infections among pregnant persons registered in the Brazilian Information System for Notifiable Diseases (Sistema de Informação de Agravos de Notificaçao, SINAN-Zika) and cases of microcephaly among live births registered in the Public Health Event Registration System (Registro de Eventos em Saúde Pública, RESP-Microcefalia) and the Live Birth Information System (Sistema de Informações Sobre Nascidos Vivos, SINASC) were georeferenced based on residential address and aggregated within census tracts. Spatial autocorrelation was performed using the bivariate global and local Moran's I indices, which considered the incidence rates of maternal ZIKV infections and microcephaly during the epidemic (2015-2017) and post-epidemic (2018-2021) time periods in relation to each other as well as social, economic, sanitation, and urban infrastructure covariates derived from the 2010 census.
resultsFrom 2015 to 2021, the city of Recife registered 253 cases (n = 240 in 2015-2017 and n = 13 in 2018-2021) of ZIKV infection in pregnant persons and 147 cases (n = 137 in 2015-2017 and n = 10 in 2018-2021) of microcephaly in newborns. The global bivariate Moran's I index between the incidences of ZIKV infection in pregnant persons and microcephaly were 0.127 (p = 0.001) in 2015-2017 and 0.074 (p = 0.002) in 2018-2021, indicating a positive spatial correlation, as higher was the ZIKV infection in pregnant persons, higher was the incidence of microcephaly. Furthermore, incidences of maternal ZIKV infection and microcephaly were consistently associated with indicators of greater social vulnerability and economic deprivation at the census tract level.
conclusionDuring the epidemic and post-epidemic periods in Recife, cases of ZIKV in pregnant persons and microcephaly were concentrated in census tracts with relatively higher socioeconomic vulnerability, reinforcing the need for research to inform the development of social protection and environmental policies to mitigate ZIKV-related risks.
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