ArticlePloS one2025
A study of the relationship between cough and wheezing complicated by common respiratory viral infections in infants and secondary thrombocythemia.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Clinical characteristics, co-detection patterns and prognostic risk factors of human metapneumovirus infection in children: a retrospective study.Frontiers in cellular and infection microbiology · 2026Article
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Abstract
objectiveTo explore the relationship between respiratory viral infections complicated by cough and wheezing and the clinical features of thrombocythemia in infants.
methodsWe retrospectively analyzed the clinical data of 200 infants with fever, cough and wheezing who were admitted to the Department of Pediatrics of Anqing Municipal Hospital between January 2023 and October 2024. Respiratory viruses were detected using real-time PCR to screen for virus-positive infants. Infants were classified into the thrombocythemia group (ST group) and the non-thrombocythemia group (non-ST group) based on platelet counts. We compared the clinical characteristics of the two groups and analyzed the relationships between thrombocythemia, positive respiratory virus results, and cough with wheezing.
resultsThe overall virus positivity detection rate was 56.5% (113/200). In the ST group, patients with positive respiratory virus results had significantly longer hospital stays, higher fever incidence, and more severe cough symptoms (P < 0.05), and significantly higher leukocyte and interleukin-6 (IL-6) levels (P < 0.05). Among the virus-positive cases, the duration of fever, cough, and wheezing was longer in the ST group than in the non-ST group (P < 0.05). Higher platelet counts were significantly associated with longer hospitalization duration, prolonged cough duration and a higher co-occurring wheezing rate (p < 0.05). Point-biserial correlation analysis indicated that thrombocythemia was closely associated with respiratory virus positivity complicated by cough and wheeze (r = 0.314, P < 0.05). Multifactorial analysis revealed that age, non-respiratory symptoms, platelet levels, and IL-6 level were independent influencing factors for respiratory virus-positive infants with complicated cough and wheezing (P < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the areas under the curve of thrombocythemia for assessing hospital stay duration and cough and wheeze durations were 0.964 and 0.936, respectively (P < 0.05), indicating a significant assessment value.
conclusionInfant respiratory viral infections complicated by cough and wheezing are closely related to secondary thrombocythemia. Elevated platelet levels can prolong the hospital stay and cough duration. The clinical risk in children can be assessed early by measuring platelet levels.
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